{"id":"isobaric-2-chloroprocaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient neurological symptoms (TNS)"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Back pain"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL1179047","moleculeType":"Small molecule","molecularWeight":"270.76"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a local anesthetic agent, 2-chloroprocaine works by inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and conduction of action potentials. The isobaric formulation is designed to have a specific gravity matching cerebrospinal fluid, allowing for controlled distribution when administered intrathecally. This enables localized anesthesia with predictable spread and duration.","oneSentence":"Isobaric 2-chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:50:17.895Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgical procedures"},{"name":"Intrathecal anesthesia for spinal procedures"}]},"trialDetails":[{"nctId":"NCT03993314","phase":"PHASE2","title":"Optimizing Anesthesia for Post Partum Tubal Ligations","status":"TERMINATED","sponsor":"University of Alabama at Birmingham","startDate":"2019-08-13","conditions":"Pregnancy Related","enrollment":15},{"nctId":"NCT03038958","phase":"PHASE4","title":"Comparison of Hyperbaric Prilocaine With Chloroprocaine for Intrathecal Anaesthesia in Day Case Knee Arthroscopy","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Saint Pierre","startDate":"2016-04","conditions":"Knee Arthroscopy, Spinal Anesthesia","enrollment":80},{"nctId":"NCT03882489","phase":"","title":"Estimation of Effective Dose 95 (ED95) of Intrathecal Isobaric 2-chloroprocaine (2-CP) Based on the Height (cm) of a Patient Undergoing Ambulatory Knee Arthroscopy","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Saint Pierre","startDate":"2019-04-11","conditions":"Knee Arthroscopy","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ampres","Ampres 10mg/ml"],"phase":"marketed","status":"active","brandName":"Isobaric 2-chloroprocaine","genericName":"Isobaric 2-chloroprocaine","companyName":"Centre Hospitalier Universitaire Saint Pierre","companyId":"centre-hospitalier-universitaire-saint-pierre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Isobaric 2-chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. Used for Local and regional anesthesia for surgical procedures, Intrathecal anesthesia for spinal procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}