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Xylocaine Injectable Solution
Xylocaine (lidocaine) is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Xylocaine (lidocaine) is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve block, and topical use, Pain relief during minor surgical and dental procedures.
At a glance
| Generic name | Xylocaine Injectable Solution |
|---|---|
| Also known as | Multimodal Analgesia Protocol |
| Sponsor | University of Puerto Rico |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes. This prevents depolarization and the propagation of action potentials along sensory and motor nerves. The injectable solution is used to produce local anesthesia by infiltration, nerve block, or topical application to specific tissues.
Approved indications
- Local anesthesia for infiltration, nerve block, and topical use
- Pain relief during minor surgical and dental procedures
Common side effects
- Lightheadedness or dizziness
- Nervousness or anxiety
- Tremor
- Allergic reactions (rare)
- Methemoglobinemia (with high doses)
Key clinical trials
- Comparison of the Effectiveness of Exercise, Dry Needling and Interfascial Block Treatments in the Treatment of Myofascial Pain Syndrome (NA)
- Subcutaneous Nitroglycerin to Facilitate Trans-radial Access. (PHASE4)
- Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery (PHASE2)
- Efficacy of Autologous Conditioned Serum in Temporomandibular Joint Disorder (NA)
- Effects of Dextrose Prolotherapy in Rotator Cuff Disease (NA)
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections (PHASE4)
- The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients (PHASE3)
- Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |