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Proparacaine Ophthalmic
Proparacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission in the eye.
Proparacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission in the eye. Used for Topical anesthesia for ophthalmic procedures and examinations, Corneal anesthesia for diagnostic procedures.
At a glance
| Generic name | Proparacaine Ophthalmic |
|---|---|
| Also known as | Proparacaine, proparacaine hydrochloride 0.5% |
| Sponsor | American Genomics, LLC |
| Drug class | Local anesthetic (ester) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | FDA-approved |
Mechanism of action
Proparacaine reversibly inhibits sodium influx through nerve cell membranes, preventing depolarization and conduction of pain impulses. This topical anesthetic effect is localized to the ocular surface and anterior structures, providing rapid onset of anesthesia suitable for ophthalmic procedures and diagnostic examinations.
Approved indications
- Topical anesthesia for ophthalmic procedures and examinations
- Corneal anesthesia for diagnostic procedures
Common side effects
- Corneal epithelial toxicity with prolonged use
- Transient stinging or burning upon instillation
- Allergic conjunctivitis
- Mydriasis
Key clinical trials
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections (PHASE4)
- Efficacy of Nanodropper-mediated Topical Anesthetic (PHASE4)
- Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients (NASA)
- Subthreshold Micropulse Laser Therapy (SML) in Retinitis Pigmentosa (NA)
- An Investigation of the Impact of Localized Topical Anesthesia of the Ocular Surface on End-of-day Contact Lens Discomfort (NA)
- Optic Nerve Head Structural Response to IOP Elevation in Patients With Keratoconus (NA)
- Base Curves of Bandage Contact Lenses and Their Effects on Post Trans-PRK Vision and Pain (NA)
- VisuMax Femtosecond Laser Small Incision Lenticule Extraction for the Correction of High Myopia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Proparacaine Ophthalmic CI brief — competitive landscape report
- Proparacaine Ophthalmic updates RSS · CI watch RSS
- American Genomics, LLC portfolio CI