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Bupivacaine 0.5% (hyperbaric)
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Spinal anesthesia for surgical procedures, Local and regional anesthesia for pain management.
At a glance
| Generic name | Bupivacaine 0.5% (hyperbaric) |
|---|---|
| Also known as | Heavy Marcaine |
| Sponsor | Nazmy Edward Seif |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and conduction of nerve impulses. The hyperbaric formulation (containing dextrose) increases the specific gravity of the solution, allowing it to settle dependently in the cerebrospinal fluid when used for spinal anesthesia. This property enables more predictable and localized anesthetic distribution in the subarachnoid space.
Approved indications
- Spinal anesthesia for surgical procedures
- Local and regional anesthesia for pain management
Common side effects
- Hypotension
- Bradycardia
- Headache (post-dural puncture)
- Neurological toxicity (at high doses)
- Cardiac arrhythmias (at high doses)
Key clinical trials
- Comparison of Intrathecal Nalbuphine Versus Intrathecal Tramadol as Adjuvants in Subarachnoid Block for Lower Limb Orthopaedic Surgeries (NA)
- Intrathecal Bupivacaine With or Without Dexmetomidine for Cesserian Delivery (PHASE2)
- Bupivacaine for Postoperative Pain After Laparoscopic Hysterectomy (NA)
- The Effect of Epidural Anesthesia on Optic Nerve Sheath Diameter Measurements in Total Knee Prosthesis Surgery (NA)
- Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty (NA)
- Maternal Satisfaction After Spinal Anesthesia for Cesarean Delivery
- Comparing Doses of Intrathecal Dexmedetomidine (PHASE4)
- Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine 0.5% (hyperbaric) CI brief — competitive landscape report
- Bupivacaine 0.5% (hyperbaric) updates RSS · CI watch RSS
- Nazmy Edward Seif portfolio CI