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Bupivacaine 0.5% (hyperbaric)

Nazmy Edward Seif · FDA-approved active Small molecule

Bupivacaine 0.5% (hyperbaric) is a Local anesthetic (amide class) Small molecule drug developed by Nazmy Edward Seif. It is currently FDA-approved for Spinal anesthesia for surgical procedures, Local and regional anesthesia for pain management. Also known as: Heavy Marcaine.

Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.

Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Spinal anesthesia for surgical procedures, Local and regional anesthesia for pain management.

At a glance

Generic nameBupivacaine 0.5% (hyperbaric)
Also known asHeavy Marcaine
SponsorNazmy Edward Seif
Drug classLocal anesthetic (amide class)
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaAnesthesia
PhaseFDA-approved

Mechanism of action

Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and conduction of nerve impulses. The hyperbaric formulation (containing dextrose) increases the specific gravity of the solution, allowing it to settle dependently in the cerebrospinal fluid when used for spinal anesthesia. This property enables more predictable and localized anesthetic distribution in the subarachnoid space.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Bupivacaine 0.5% (hyperbaric)

What is Bupivacaine 0.5% (hyperbaric)?

Bupivacaine 0.5% (hyperbaric) is a Local anesthetic (amide class) drug developed by Nazmy Edward Seif, indicated for Spinal anesthesia for surgical procedures, Local and regional anesthesia for pain management.

How does Bupivacaine 0.5% (hyperbaric) work?

Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.

What is Bupivacaine 0.5% (hyperbaric) used for?

Bupivacaine 0.5% (hyperbaric) is indicated for Spinal anesthesia for surgical procedures, Local and regional anesthesia for pain management.

Who makes Bupivacaine 0.5% (hyperbaric)?

Bupivacaine 0.5% (hyperbaric) is developed and marketed by Nazmy Edward Seif (see full Nazmy Edward Seif pipeline at /company/nazmy-edward-seif).

Is Bupivacaine 0.5% (hyperbaric) also known as anything else?

Bupivacaine 0.5% (hyperbaric) is also known as Heavy Marcaine.

What drug class is Bupivacaine 0.5% (hyperbaric) in?

Bupivacaine 0.5% (hyperbaric) belongs to the Local anesthetic (amide class) class. See all Local anesthetic (amide class) drugs at /class/local-anesthetic-amide-class.

What development phase is Bupivacaine 0.5% (hyperbaric) in?

Bupivacaine 0.5% (hyperbaric) is FDA-approved (marketed).

What are the side effects of Bupivacaine 0.5% (hyperbaric)?

Common side effects of Bupivacaine 0.5% (hyperbaric) include Hypotension, Bradycardia, Headache (post-dural puncture), Neurological toxicity (at high doses), Cardiac arrhythmias (at high doses).

What does Bupivacaine 0.5% (hyperbaric) target?

Bupivacaine 0.5% (hyperbaric) targets Voltage-gated sodium channels and is a Local anesthetic (amide class).

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