Bupivacaine 0.5% (hyperbaric) — Competitive Intelligence Brief

Bupivacaine 0.5% (hyperbaric) (Bupivacaine 0.5% (hyperbaric)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic (amide class). Area: Anesthesia.

marketed Local anesthetic (amide class) Voltage-gated sodium channels Anesthesia Small molecule

Target snapshot

Bupivacaine 0.5% (hyperbaric) (Bupivacaine 0.5% (hyperbaric)) — Nazmy Edward Seif. Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Bupivacaine 0.5% (hyperbaric) TARGET	Bupivacaine 0.5% (hyperbaric)	Nazmy Edward Seif	marketed	Local anesthetic (amide class)	Voltage-gated sodium channels
Anesthetics, Local	Anesthetics, Local	University of Alberta	marketed	Local anesthetic	Voltage-gated sodium channels
Lidocaine 2% Injectable Solution	Lidocaine 2% Injectable Solution	Erasme University Hospital	marketed	Local anesthetic	Voltage-gated sodium channels
Lidocaine 2% Jelly	Lidocaine 2% Jelly	Hermann Eye Center	marketed	Local anesthetic	Voltage-gated sodium channels
Levobupivacaine and Fentanyl	Levobupivacaine and Fentanyl	Hamad Medical Corporation	marketed	Local anesthetic with opioid analgesic combination	Voltage-gated sodium channels; mu-opioid receptor
Lidocaine plus adrenaline	Lidocaine plus adrenaline	University of Santiago de Compostela	marketed	Local anesthetic with vasopressor	Voltage-gated sodium channels; alpha-1 and beta-1 adrenergic receptors
lidocaine with propofol	lidocaine with propofol	Imam Abdulrahman Bin Faisal University	marketed	Local anesthetic and sedative-hypnotic combination	Voltage-gated sodium channels (lidocaine); GABA-A receptors (propofol)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic (amide class) class)

1. Ain Shams University · 2 drugs in this class
2. Başakşehir Çam & Sakura City Hospital · 2 drugs in this class
3. TriHealth Inc. · 2 drugs in this class
4. Centre of Postgraduate Medical Education · 2 drugs in this class
5. Bozyaka Training and Research Hospital · 2 drugs in this class
6. Complejo Hospitalario Universitario de Granada · 1 drug in this class
7. Clinique Saint-Jean, Bruxelles · 1 drug in this class
8. Hospital Clínico Universitario de Valencia · 1 drug in this class
9. Fundacion Clinica Valle del Lili · 1 drug in this class
10. Federal University of Minas Gerais · 1 drug in this class