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Lidocaine plus adrenaline
Lidocaine blocks sodium channels to provide local anesthesia, while adrenaline (epinephrine) causes vasoconstriction to prolong anesthetic duration and reduce systemic toxicity.
Lidocaine blocks sodium channels to provide local anesthesia, while adrenaline (epinephrine) causes vasoconstriction to prolong anesthetic duration and reduce systemic toxicity. Used for Local and regional anesthesia for surgical and dental procedures, Infiltration anesthesia for minor surgical procedures.
At a glance
| Generic name | Lidocaine plus adrenaline |
|---|---|
| Also known as | anaesthesia |
| Sponsor | University of Santiago de Compostela |
| Drug class | Local anesthetic with vasopressor |
| Target | Voltage-gated sodium channels; alpha-1 and beta-1 adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that reversibly inhibits sodium influx in nerve cell membranes, preventing depolarization and action potential propagation. Adrenaline is a sympathomimetic agent that causes vasoconstriction of local blood vessels, which slows the systemic absorption of lidocaine, extends its duration of action at the injection site, and reduces the risk of toxicity by maintaining local drug concentration.
Approved indications
- Local and regional anesthesia for surgical and dental procedures
- Infiltration anesthesia for minor surgical procedures
Common side effects
- Injection site reactions (pain, erythema)
- Transient hypertension
- Tachycardia
- Headache
- Dizziness
- Allergic reactions (rare)
Key clinical trials
- Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
- Single Gene Polymorphism and the Success Rate of Inferior Alveolar Nerve Block (NA)
- Pain Experience Using Lidocaine Adrenaline Tetracaine (LAT) Gel Versus Lidocaine Infiltration for Laceration Repair in Adults (PHASE4)
- Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (NA)
- This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis. (NA)
- A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses Standard of Care in Adhesive Capsulitis of the Shoulder (PHASE4)
- Reducing Side-effects of Autologous Skin Tissue Harvesting (EARLY_PHASE1)
- Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Split Mouth Randomized Study (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine plus adrenaline CI brief — competitive landscape report
- Lidocaine plus adrenaline updates RSS · CI watch RSS
- University of Santiago de Compostela portfolio CI