Last reviewed 2026-04-22 · How we verify

Lidocaine 2% Injectable Solution

Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia.

Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Local anesthesia for infiltration, nerve blocks, and regional anesthesia, Topical anesthesia for minor surgical and diagnostic procedures.

At a glance

Mechanism of action

Lidocaine is a local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve fibers. By blocking these channels, it prevents depolarization and the generation of action potentials, thereby interrupting nerve conduction and producing localized loss of sensation. It has a rapid onset and intermediate duration of action.

Approved indications

• Local anesthesia for infiltration, nerve blocks, and topical application
• Ventricular arrhythmias (intravenous formulation)

Common side effects

• Injection site reactions (pain, erythema)
• Dizziness or lightheadedness
• Tremor or nervousness
• Nausea
• Allergic reactions (rare with amide lidocaine)

Key clinical trials

• Comparison of the Effectiveness of Exercise, Dry Needling and Interfascial Block Treatments in the Treatment of Myofascial Pain Syndrome (NA)
• Subcutaneous Nitroglycerin to Facilitate Trans-radial Access. (PHASE4)
• Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery (PHASE2)
• Efficacy of Autologous Conditioned Serum in Temporomandibular Joint Disorder (NA)
• Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections (PHASE4)
• Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA (PHASE4)
• The Use of Lidocaine Gel Versus Subconjunctival Xylocaine Injection in Pterygium Excision (PHASE4)
• Comparison of the Effect of Genicular Nerve Block and Physical Therapy in Patients With Knee Osteoarthritis (NA)

Primary sources

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