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Levobupivacaine and Fentanyl
Levobupivacaine blocks sodium channels to provide local anesthesia, while fentanyl activates opioid receptors to provide analgesia.
Levobupivacaine blocks sodium channels to provide local anesthesia, while fentanyl activates opioid receptors to provide analgesia. Used for Local and regional anesthesia with analgesia.
At a glance
| Generic name | Levobupivacaine and Fentanyl |
|---|---|
| Sponsor | Hamad Medical Corporation |
| Drug class | Local anesthetic with opioid analgesic combination |
| Target | Voltage-gated sodium channels; mu-opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
Levobupivacaine is the S-enantiomer of bupivacaine that reversibly inhibits sodium influx in nerve fibers, preventing action potential propagation and local anesthetic effect. Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central and peripheral nervous system to produce analgesia and potentiate the analgesic effect of the local anesthetic.
Approved indications
- Local and regional anesthesia with analgesia
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Dizziness
- Headache
- Respiratory depression
Key clinical trials
- Efficacy of Scalp Block in Managing Post Subarachnoid Hemorrhage Headache in Critically Ill Patients. A Single Centre Randomized Controlled Trial (NA)
- Investigation of Antibacterial Effect of Levobupivacaine on Staphylococcus Aureus (NA)
- Efficacy of Magnesium Sulfate as an Adjuvant in Erector Spinae Plane Block as an Anesthetic Post Operative After Modified Radical Mastectomy (EARLY_PHASE1)
- Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures (PHASE4)
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
- Dexamethasone As Adjuvant for Pre - emptiveTransversusAbdominus Muscle Plane Block (NA)
- Comparative Study Between Intrathecal (Dexmedetomidine Versus Fentanyl) (NA)
- Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Levobupivacaine and Fentanyl CI brief — competitive landscape report
- Levobupivacaine and Fentanyl updates RSS · CI watch RSS
- Hamad Medical Corporation portfolio CI