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lidocaine with propofol
Lidocaine and propofol together provide local anesthesia and intravenous sedation by blocking sodium channels and enhancing GABAergic inhibition, respectively.
Lidocaine and propofol together provide local anesthesia and intravenous sedation by blocking sodium channels and enhancing GABAergic inhibition, respectively. Used for Procedural sedation and analgesia, Local anesthesia during minor surgical procedures.
At a glance
| Generic name | lidocaine with propofol |
|---|---|
| Sponsor | Imam Abdulrahman Bin Faisal University |
| Drug class | Local anesthetic and sedative-hypnotic combination |
| Target | Voltage-gated sodium channels (lidocaine); GABA-A receptors (propofol) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that blocks voltage-gated sodium channels in nerve fibers, preventing action potential propagation and pain signal transmission. Propofol is a sedative-hypnotic agent that acts as a positive allosteric modulator of GABA-A receptors, enhancing inhibitory neurotransmission in the central nervous system. The combination is used to provide both local anesthesia and systemic sedation during procedures.
Approved indications
- Procedural sedation and analgesia
- Local anesthesia during minor surgical procedures
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Dizziness
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- Study Comparing Local/ MAC Anesthesia in Lumbar Decompression (EARLY_PHASE1)
- General Anesthesia and General Anesthesia Combined With Thoracic Epidural Anesthesia (NA)
- Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy (PHASE4)
- Comparison of Airway Management With Bronchial Blocker and Double-Lumen Tube in Single-Lung Ventilation (NA)
- Tubeless Strategy in Lung Transplantation: A Prospective Single-Arm Study (NA)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- lidocaine with propofol CI brief — competitive landscape report
- lidocaine with propofol updates RSS · CI watch RSS
- Imam Abdulrahman Bin Faisal University portfolio CI