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Levobupivacaine epidural bolus
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Epidural anesthesia for surgical procedures, Epidural analgesia for postoperative pain management.
At a glance
| Generic name | Levobupivacaine epidural bolus |
|---|---|
| Sponsor | University of Genova |
| Drug class | Local anesthetic (amino amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting amide local anesthetic. When administered epidurally, it diffuses across the dura mater to block voltage-gated sodium channels on nerve fibers, preventing depolarization and transmission of pain signals. The S-enantiomer formulation offers improved cardiac safety compared to the racemic mixture.
Approved indications
- Epidural anesthesia for surgical procedures
- Epidural analgesia for postoperative pain management
- Labor pain relief
Common side effects
- Hypotension
- Bradycardia
- Headache
- Nausea
- Neurological toxicity (at high doses)
- Cardiac toxicity (at high doses)
Key clinical trials
- Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy (PHASE1)
- Programmed Intermittent Epidural Bolus (PIEB) Techniques for Labour Analgesia (PHASE4)
- Optimal Postoperative Pain Management After Lung Surgery (OPtriAL) (NA)
- PIEB-PCEA Versus CEI-PCEA for Labor Analgesia in Nulliparous (NA)
- Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery (NA)
- Effectivness of Tramadol or Topic Lidocaine on Postoperative Analgesia in Laparoscopic Colorectal Resection. (NA)
- The Effects of Method of Anaesthesia on the Safety and Effectiveness of Radical Retropubic Prostatectomy (NA)
- Hemodynamic Impact of Epidural Anesthesia in Relation to Age in Pediatric Patients.
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |