{"id":"levobupivacaine-epidural-bolus","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Neurological toxicity (at high doses)"},{"rate":null,"effect":"Cardiac toxicity (at high doses)"}]},"_chembl":{"chemblId":"CHEMBL1201193","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting amide local anesthetic. When administered epidurally, it diffuses across the dura mater to block voltage-gated sodium channels on nerve fibers, preventing depolarization and transmission of pain signals. The S-enantiomer formulation offers improved cardiac safety compared to the racemic mixture.","oneSentence":"Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:51:53.332Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Epidural anesthesia for surgical procedures"},{"name":"Epidural analgesia for postoperative pain management"},{"name":"Labor pain relief"}]},"trialDetails":[{"nctId":"NCT06595329","phase":"PHASE1","title":"Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy","status":"RECRUITING","sponsor":"University Hospital of Split","startDate":"2025-01-15","conditions":"Pain, Renal Cancer, Surgical Procedure, Unspecified","enrollment":40},{"nctId":"NCT06266767","phase":"PHASE4","title":"Programmed Intermittent Epidural Bolus (PIEB) Techniques for Labour Analgesia","status":"COMPLETED","sponsor":"Hamad Medical Corporation","startDate":"2024-02-21","conditions":"Labor Pain, Obstetric Pain, Analgesia","enrollment":136},{"nctId":"NCT05491239","phase":"NA","title":"Optimal Postoperative Pain Management After Lung Surgery (OPtriAL)","status":"COMPLETED","sponsor":"Maxima Medical Center","startDate":"2021-03-01","conditions":"Lung Cancer, Pain, Postoperative, VATS","enrollment":450},{"nctId":"NCT01856166","phase":"NA","title":"PIEB-PCEA Versus CEI-PCEA for Labor Analgesia in Nulliparous","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2013-06","conditions":"Pregnancy","enrollment":304},{"nctId":"NCT06042816","phase":"NA","title":"Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery","status":"COMPLETED","sponsor":"Vietnam Military Medical University","startDate":"2019-12-30","conditions":"Colorectal Cancer","enrollment":49},{"nctId":"NCT05831761","phase":"NA","title":"Effectivness of Tramadol or Topic Lidocaine on Postoperative Analgesia in Laparoscopic Colorectal Resection.","status":"COMPLETED","sponsor":"University Medical Centre Ljubljana","startDate":"2009-09-01","conditions":"Postoperative Pain","enrollment":83},{"nctId":"NCT05566405","phase":"NA","title":"The Effects of Method of Anaesthesia on the Safety and Effectiveness of Radical Retropubic Prostatectomy","status":"COMPLETED","sponsor":"Sismanoglio General Hospital","startDate":"2020-07-27","conditions":"Prostatic Neoplasm","enrollment":60},{"nctId":"NCT05543824","phase":"","title":"Hemodynamic Impact of Epidural Anesthesia in Relation to Age in Pediatric Patients.","status":"UNKNOWN","sponsor":"Hospital Universitario La Fe","startDate":"2022-09-12","conditions":"Hemodynamic Monitoring, Anesthesia; Adverse Effect, Pediatric Major Surgery","enrollment":15},{"nctId":"NCT04531553","phase":"NA","title":"Erector Spinae Plane Block for Post-thoracotomy Pain Control","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2021-03-03","conditions":"Post-thoracotomy Pain Syndrome","enrollment":90},{"nctId":"NCT05196256","phase":"PHASE3","title":"Study Comparing Dural Puncture Epidural With Epidural and Combined Spinal Epidural Anesthesia for Obstetric Analgesia.","status":"UNKNOWN","sponsor":"Brugmann University Hospital","startDate":"2022-06-30","conditions":"Obstetric Pain, Analgesia","enrollment":90},{"nctId":"NCT02848599","phase":"PHASE2","title":"The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery","status":"COMPLETED","sponsor":"Osijek University Hospital","startDate":"2016-07","conditions":"Postoperative Cognitive Dysfunction","enrollment":86},{"nctId":"NCT03933592","phase":"NA","title":"Ultrasound Guided Serratus Plane Block Versus Thoracic Epidural for Post Thoracotomy Pain","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2019-06-10","conditions":"Ultrasound Guided Serratus Plane Block, Thoracic Epidural, Post Thoracotomy Pain","enrollment":60},{"nctId":"NCT03381690","phase":"","title":"Preoperative Epidural Labor Analgesia and Postoperative Pain","status":"COMPLETED","sponsor":"Seoul National University Bundang Hospital","startDate":"2017-09-01","conditions":"Cesarean Section","enrollment":222},{"nctId":"NCT02563821","phase":"PHASE3","title":"Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG)","status":"COMPLETED","sponsor":"University Hospital, Limoges","startDate":"2015-11-05","conditions":"Anesthesia, Epidural","enrollment":37},{"nctId":"NCT03133091","phase":"PHASE3","title":"Epidural Analgesia During Labour","status":"COMPLETED","sponsor":"Hospital del Rio Hortega","startDate":"2015-09","conditions":"Anesthesia, Obstetrical, Analgesia, Epidural","enrollment":200},{"nctId":"NCT03580980","phase":"NA","title":"Multimodal Analgesia in Major Abdominal Pediatric Cancer Surgeries","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2015-04-01","conditions":"Pediatric Cancer, Pain, Postoperative","enrollment":90},{"nctId":"NCT02705872","phase":"PHASE2","title":"Comparison of Two Methods of Administration of the Epidural, by Programmed Intermittent Bolus or Continuous Perfusion, on the Incidence of Cesarean Sections and Instrumented Deliveries in Primiparous Women","status":"WITHDRAWN","sponsor":"Brugmann University Hospital","startDate":"2016-03-08","conditions":"First Child Delivery With Epidural","enrollment":""},{"nctId":"NCT02710877","phase":"NA","title":"Intermittent Automated Devices for Labor Analgesia in Emilia Romagna","status":"TERMINATED","sponsor":"University of Modena and Reggio Emilia","startDate":"2014-12-23","conditions":"Labor Pain","enrollment":671},{"nctId":"NCT03407209","phase":"NA","title":"Compared Efficacy of Patient-controlled Epidural Analgesia With or Without Automatic Boluses","status":"COMPLETED","sponsor":"University Hospital, Caen","startDate":"2016-11-06","conditions":"Delivery","enrollment":462},{"nctId":"NCT02677532","phase":"PHASE4","title":"Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair","status":"COMPLETED","sponsor":"University of Genova","startDate":"2011-12","conditions":"Postoperative Pain","enrollment":51},{"nctId":"NCT02042313","phase":"PHASE4","title":"Postoperative Pain Management After Minimally Invasive Esophagectomy","status":"UNKNOWN","sponsor":"Sun Yat-sen University","startDate":"2014-02","conditions":"Esophageal Cancer","enrollment":58},{"nctId":"NCT02478372","phase":"NA","title":"Patient Controlled Epidural Analgesia Versus Local Infiltration Analgesia Following Knee Arthroplasty","status":"COMPLETED","sponsor":"Golden Jubilee National Hospital","startDate":"2010-04","conditions":"Osteoarthritis","enrollment":242},{"nctId":"NCT01860521","phase":"NA","title":"Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Termination of Pregnancy Analgesia","status":"COMPLETED","sponsor":"IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","startDate":"2011-09","conditions":"Medical; Abortion, Fetus","enrollment":104},{"nctId":"NCT01249872","phase":"PHASE2, PHASE3","title":"Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens","status":"COMPLETED","sponsor":"University of Patras","startDate":"2010-01","conditions":"Morbid Obesity, Postoperative Pain, Postoperative Bowel Function","enrollment":96},{"nctId":"NCT01558713","phase":"PHASE2, PHASE3","title":"Epidural Volume Extension and Intrathecal Use of Local Anesthetics in Cesarean Sections","status":"UNKNOWN","sponsor":"University of Patras","startDate":"2010-01","conditions":"Stillborn Caesarean Section","enrollment":120},{"nctId":"NCT00552864","phase":"PHASE4","title":"Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia","status":"COMPLETED","sponsor":"Centro Cardiologico Monzino","startDate":"2003-01","conditions":"Coronary Artery Bypass, Epidural Anesthesia","enrollment":61}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":24,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Levobupivacaine epidural bolus","genericName":"Levobupivacaine epidural bolus","companyName":"University of Genova","companyId":"university-of-genova","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Epidural anesthesia for surgical procedures, Epidural analgesia for postoperative pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}