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Chloroprocaine Injection [Clorotekal]
Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local infiltration anesthesia, Peripheral nerve blocks, Epidural anesthesia.
At a glance
| Generic name | Chloroprocaine Injection [Clorotekal] |
|---|---|
| Also known as | Clorotekal |
| Sponsor | Oregon Health and Science University |
| Drug class | Local anesthetic (ester) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Chloroprocaine is an ester-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby stabilizing the neuronal membrane and preventing depolarization. This action blocks the generation and propagation of action potentials in sensory, motor, and autonomic nerves. It has rapid onset and short duration of action, making it suitable for infiltration anesthesia and nerve blocks.
Approved indications
- Local infiltration anesthesia
- Peripheral nerve blocks
- Epidural anesthesia
Common side effects
- Systemic toxicity (CNS and cardiovascular effects)
- Allergic reactions
- Methemoglobinemia
- Local tissue irritation