{"id":"chloroprocaine-injection-clorotekal","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS and cardiovascular effects)"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Methemoglobinemia"},{"rate":null,"effect":"Local tissue irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chloroprocaine is an ester-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby stabilizing the neuronal membrane and preventing depolarization. This action blocks the generation and propagation of action potentials in sensory, motor, and autonomic nerves. It has rapid onset and short duration of action, making it suitable for infiltration anesthesia and nerve blocks.","oneSentence":"Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:30:01.955Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local infiltration anesthesia"},{"name":"Peripheral nerve blocks"},{"name":"Epidural anesthesia"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":105,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Clorotekal"],"phase":"marketed","status":"active","brandName":"Chloroprocaine Injection [Clorotekal]","genericName":"Chloroprocaine Injection [Clorotekal]","companyName":"Oregon Health and Science University","companyId":"oregon-health-and-science-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local infiltration anesthesia, Peripheral nerve blocks, Epidural anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}