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bupivacaine 0.25 % injection
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.
At a glance
| Generic name | bupivacaine 0.25 % injection |
|---|---|
| Sponsor | Ain Shams University |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and action potential generation. This blocks conduction of sensory, motor, and autonomic nerve impulses in a dose-dependent manner. The drug is long-acting due to its high lipophilicity and protein binding, allowing sustained local anesthesia at the injection site.
Approved indications
- Local and regional anesthesia for surgical procedures
- Infiltration anesthesia
- Nerve blocks
- Epidural and spinal anesthesia
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures, loss of consciousness)
- Cardiovascular effects (hypotension, bradycardia, arrhythmias)
- Local reactions (pain, erythema at injection site)
- Allergic reactions
- Methemoglobinemia
Key clinical trials
- Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block for Analgesia in Arthroscopic Shoulder Surgery (NA)
- Arthrosemid vs. Steroid for the Management Knee Osteoarthritis (PHASE4)
- Parascapular Sub Iliocostalis Plane Block Versus Thoracic Paravertebral Plane Block for Traumatic Multiple Rib Fractures (NA)
- Retrolaminar Block Versus Subcostal Transversus Abdominis Plane Block in Liver Resection Surgery (NA)
- Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (NA)
- Rhomboid Intercostal Block vs Erector Spinae Block (NA)
- Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- bupivacaine 0.25 % injection CI brief — competitive landscape report
- bupivacaine 0.25 % injection updates RSS · CI watch RSS
- Ain Shams University portfolio CI