{"id":"bupivacaine-0-25-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS effects: tremor, seizures, loss of consciousness)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, bradycardia, arrhythmias)"},{"rate":null,"effect":"Local reactions (pain, erythema at injection site)"},{"rate":"rare","effect":"Allergic reactions"},{"rate":"rare","effect":"Methemoglobinemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and action potential generation. This blocks conduction of sensory, motor, and autonomic nerve impulses in a dose-dependent manner. The drug is long-acting due to its high lipophilicity and protein binding, allowing sustained local anesthesia at the injection site.","oneSentence":"Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:40:54.716Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgical procedures"},{"name":"Infiltration anesthesia"},{"name":"Nerve blocks"},{"name":"Epidural and spinal anesthesia"}]},"trialDetails":[{"nctId":"NCT07394673","phase":"NA","title":"Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block for Analgesia in Arthroscopic Shoulder Surgery","status":"RECRUITING","sponsor":"Bursa City Hospital","startDate":"2026-02-20","conditions":"Postoperative Pain, Acute, Shoulder Pain, Serratus Posterior Superior Intercostal Plane 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