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Bupivacaine 0.125%
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local and regional anesthesia for infiltration, nerve block, and epidural/spinal procedures.
At a glance
| Generic name | Bupivacaine 0.125% |
|---|---|
| Also known as | Plain marcaine, Marcaine |
| Sponsor | Shanghai Pulmonary Hospital, Shanghai, China |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and action potential propagation. This results in a loss of sensation in the infiltrated tissue. The drug has a relatively long duration of action compared to other local anesthetics due to its high lipophilicity and protein binding.
Approved indications
- Local and regional anesthesia for infiltration, nerve block, and epidural/spinal procedures
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures, loss of consciousness)
- Cardiovascular effects (hypotension, bradycardia, arrhythmias)
- Local reactions (pain, erythema at injection site)
- Allergic reactions
Key clinical trials
- Parascapular Sub Iliocostalis Plane Block Versus Thoracic Paravertebral Plane Block for Traumatic Multiple Rib Fractures (NA)
- Epidural vs. Dural Puncture Epidural in Labor Analgesia (NA)
- Thoracic Epidural Analgesia With Bilateral Erector Spinae Plane Block in Radical Cystectomy Surgery (NA)
- Bilateral Two Levels Serratus Anterior Plane Block in Pediatric Cardiac Surgery With Median Sternotomy (NA)
- Comparison of Caudal and Quadratus Lumborum Blocks With Pain Monitoring in Children
- Intrapleural Bupivacaine Analgesia for Postoperative Pain Management After Minimally Invasive Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial (PHASE4)
- Spinal Anesthesia For Enhanced Recovery After Liver Surgery (NA)
- Dural Puncture Epidural vs Standard Epidural Analgesia in Labor (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine 0.125% CI brief — competitive landscape report
- Bupivacaine 0.125% updates RSS · CI watch RSS
- Shanghai Pulmonary Hospital, Shanghai, China portfolio CI