{"id":"bupivacaine-0-125","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS effects: tremor, seizures, loss of consciousness)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, bradycardia, arrhythmias)"},{"rate":null,"effect":"Local reactions (pain, erythema at injection site)"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and action potential propagation. This results in a loss of sensation in the infiltrated tissue. The drug has a relatively long duration of action compared to other local anesthetics due to its high lipophilicity and protein binding.","oneSentence":"Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:28:59.935Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for infiltration, nerve block, and epidural/spinal procedures"}]},"trialDetails":[{"nctId":"NCT07493473","phase":"NA","title":"Parascapular Sub Iliocostalis Plane Block Versus Thoracic Paravertebral Plane Block for Traumatic Multiple Rib Fractures","status":"ACTIVE_NOT_RECRUITING","sponsor":"Zagazig University","startDate":"2025-05-01","conditions":"Discitis of Thoracic Region","enrollment":36},{"nctId":"NCT06849726","phase":"NA","title":"Epidural vs. Dural Puncture Epidural in Labor 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