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Bupivacaine Digital Block
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia. Used for Digital nerve block for surgical anesthesia of fingers and hand, Regional anesthesia for hand and finger procedures.
At a glance
| Generic name | Bupivacaine Digital Block |
|---|---|
| Sponsor | University of California, San Francisco |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and nerve impulse transmission. When administered as a digital block (injection around nerves supplying the fingers), it produces localized anesthesia of the hand and fingers. The drug is long-acting compared to other local anesthetics due to its high lipophilicity and protein binding.
Approved indications
- Digital nerve block for surgical anesthesia of fingers and hand
- Regional anesthesia for hand and finger procedures
Common side effects
- Transient paresthesia
- Temporary numbness beyond intended duration
- Systemic toxicity (if absorbed in high concentrations)
- Allergic reaction (rare with amide local anesthetics)
Key clinical trials
- Resiniferatoxin for the Management of Refractory Morton s Neuroma Pain (PHASE1)
- Comparing General Anesthesia With Single Injection Peribulbar Block With 3 Different Drugs (NA)
- Intercostal Nerve Block for Pain Management After Uniportal Video-assisted Thoracoscopic Surgeries (NA)
- Sphenopalatine Ganglion Block with Bupivacaine and Its Effect on Pain After Functional Endoscopic Sinus Surgery (NA)
- Motor Sparing Supraclavicular Block (NA)
- Comparison Between Peribulbar And Sub-tenon Blocks on Oculocardiac Reflex (OCR) During Pediatric Strabismus Surgery (NA)
- Nerve Block of the Proximal Interphalangeal Joints PIPs in Rheumatoid Arthritis (RA) Patients: a Prospective Pilot Study (NA)
- Determination of the Duration of Action of a Lidocaine and a Bupivacaine Digital Nerve Block in Human Volunteers (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine Digital Block CI brief — competitive landscape report
- Bupivacaine Digital Block updates RSS · CI watch RSS
- University of California, San Francisco portfolio CI