{"id":"bupivacaine-digital-block","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient paresthesia"},{"rate":null,"effect":"Temporary numbness beyond intended duration"},{"rate":null,"effect":"Systemic toxicity (if absorbed in high concentrations)"},{"rate":null,"effect":"Allergic reaction (rare with amide local anesthetics)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and nerve impulse transmission. When administered as a digital block (injection around nerves supplying the fingers), it produces localized anesthesia of the hand and fingers. The drug is long-acting compared to other local anesthetics due to its high lipophilicity and protein binding.","oneSentence":"Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:41:04.707Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Digital nerve block for surgical anesthesia of fingers and hand"},{"name":"Regional anesthesia for hand and finger procedures"}]},"trialDetails":[{"nctId":"NCT05695339","phase":"PHASE1","title":"Resiniferatoxin for the Management of Refractory Morton s Neuroma Pain","status":"RECRUITING","sponsor":"National Institutes of Health Clinical Center (CC)","startDate":"2025-03-13","conditions":"Morton's Neuroma","enrollment":24},{"nctId":"NCT05728151","phase":"NA","title":"Comparing General Anesthesia With Single Injection Peribulbar Block With 3 Different Drugs","status":"COMPLETED","sponsor":"Research Institute of Ophthalmology, Egypt","startDate":"2022-02-22","conditions":"Pediatric Squint Surgeries","enrollment":55},{"nctId":"NCT06838026","phase":"NA","title":"Intercostal Nerve Block for Pain Management After Uniportal Video-assisted Thoracoscopic Surgeries","status":"NOT_YET_RECRUITING","sponsor":"Al-Quds University","startDate":"2025-05-05","conditions":"Thoracic, Pain, Postoperative, Analgesia","enrollment":90},{"nctId":"NCT06847425","phase":"NA","title":"Sphenopalatine Ganglion Block with Bupivacaine and Its Effect on Pain After Functional Endoscopic Sinus Surgery","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-03-20","conditions":"Anaesthesia","enrollment":70},{"nctId":"NCT06074471","phase":"NA","title":"Motor Sparing Supraclavicular Block","status":"RECRUITING","sponsor":"Cairo University","startDate":"2023-09-25","conditions":"Anesthesia, Regional Anesthesia Morbidity","enrollment":44},{"nctId":"NCT06293586","phase":"NA","title":"Comparison Between Peribulbar And Sub-tenon Blocks on Oculocardiac Reflex (OCR) During Pediatric Strabismus Surgery","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-12-01","conditions":"Anesthesia, Local, Ophthalmopathy, Strabismus","enrollment":140},{"nctId":"NCT04130178","phase":"NA","title":"Nerve Block of the Proximal Interphalangeal Joints PIPs in Rheumatoid Arthritis (RA) Patients: a Prospective Pilot Study","status":"COMPLETED","sponsor":"Sohag University","startDate":"2019-10-15","conditions":"Rheumatoid Arthritis","enrollment":48},{"nctId":"NCT01508832","phase":"PHASE4","title":"Determination of the Duration of Action of a Lidocaine and a Bupivacaine Digital Nerve Block in Human Volunteers","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2012-01","conditions":"Onset and Duration of a Digital Nerve Block","enrollment":12},{"nctId":"NCT02908412","phase":"PHASE4","title":"Non-invasive Perioperative Hb Monitoring in Spinal Surgery","status":"COMPLETED","sponsor":"Tehran University of Medical Sciences","startDate":"2017-01-04","conditions":"Blood Loss, Surgical","enrollment":23},{"nctId":"NCT02775318","phase":"PHASE1","title":"Stellate Ganglion Block Using Ultrasound Guidance For Treatment Of Post Clipping Cerebral Vasospasm","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2014-09","conditions":"Cerebral Vasospasm","enrollment":20},{"nctId":"NCT01750554","phase":"NA","title":"The Influence of a Bupivacaine Digital Nerve Block Using Rev G.","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2012-12","conditions":"Patients Undergoing Spine Surgery","enrollment":19},{"nctId":"NCT01698593","phase":"NA","title":"Bupivacaine Digital Blocks: How Long is the Pain Relief and Temperature Elevation?","status":"COMPLETED","sponsor":"Lalonde, Donald H., M.D.","startDate":"2009-07","conditions":"Pain","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Bupivacaine Digital Block","genericName":"Bupivacaine Digital Block","companyName":"University of California, San Francisco","companyId":"university-of-california-san-francisco","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia. Used for Digital nerve block for surgical anesthesia of fingers and hand, Regional anesthesia for hand and finger procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}