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Bupivacaine 20cc
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.
At a glance
| Generic name | Bupivacaine 20cc |
|---|---|
| Also known as | Exparel, Marcaine, Marcaine Spinal (PF) |
| Sponsor | Hospital for Special Surgery, New York |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and action potential generation. This blocks conduction of sensory, motor, and autonomic nerve impulses in the area where it is injected. The drug is long-acting due to its high lipophilicity and protein binding, allowing sustained local anesthesia.
Approved indications
- Local and regional anesthesia for surgical procedures
- Infiltration anesthesia
- Nerve blocks
- Epidural and spinal anesthesia
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Allergic reactions
- Methemoglobinemia
Key clinical trials
- The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA (NA)
- IPP Placement & Intracavernosal Block (PHASE4)
- Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations (PHASE4)
- Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery (PHASE4)
- Post Operative Infusion Pump Pain Study (PHASE4)
- Comparison of the Postoperative Analgesic Efficacy of SAP and SPSIP Blocks in Patients Undergoing Mammoplasty (NA)
- Effect of Peng Block Application on Inflammation and Mortality in Hip Fractures (NA)
- Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |