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Topical Benzocaine 20%
Benzocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Benzocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Topical anesthesia for minor cuts, wounds, and abrasions, Oral mucosal anesthesia for minor mouth and throat irritation, Temporary relief of pain and itching from minor skin conditions.
At a glance
| Generic name | Topical Benzocaine 20% |
|---|---|
| Sponsor | Nourhan M.Aly |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Benzocaine works by reversibly inhibiting sodium influx through voltage-gated sodium channels in sensory nerve fibers, which suppresses the generation and propagation of action potentials. This results in local anesthesia and numbing of the affected tissue. At 20% concentration in topical formulation, it provides rapid onset anesthesia suitable for surface application.
Approved indications
- Topical anesthesia for minor cuts, wounds, and abrasions
- Oral mucosal anesthesia for minor mouth and throat irritation
- Temporary relief of pain and itching from minor skin conditions
Common side effects
- Localized irritation or erythema
- Allergic contact dermatitis
- Methemoglobinemia (rare, with excessive use)
Key clinical trials
- DaxibotulinumtoxinA for Blepharospasm (PHASE2)
- Clinical Outcomes of Mandibular Primary Molar Extraction Using Physics Forceps in Children (NA)
- Improving Postoperative Recovery: A Study of Multimodal Perineal Analgesia Protocol (MPAP) After Vaginal Surgery (PHASE4)
- TEAS for Variceal Bleeding Endoscopy in Cirrhosis (NA)
- Effect of Pulsed Electromagnetic Field on Pruritus in Burn Scars (NA)
- Effectiveness of Needle-Free Infiltration Anesthesia in Reduction of Dental Pain and Anxiety During Local Anesthesia. (NA)
- Cryotherapy as a Topical Anesthetic in Healthy Children (PHASE4)
- Effects of Topical Anesthesia Approaches on Dental Pain During and After Restorative Management of Dental Caries (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Topical Benzocaine 20% CI brief — competitive landscape report
- Topical Benzocaine 20% updates RSS · CI watch RSS
- Nourhan M.Aly portfolio CI