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Bupivacaine indwelling catheter
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Local anesthesia via indwelling catheter for perioperative pain management, Regional anesthesia for surgical procedures.
At a glance
| Generic name | Bupivacaine indwelling catheter |
|---|---|
| Also known as | OnQ pain pump, Continuous infusion of bupivacaine |
| Sponsor | Denver Health and Hospital Authority |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and nerve impulse transmission. When delivered via an indwelling catheter, it provides continuous or intermittent local anesthetic effect at the catheter site or surrounding tissue. This allows for prolonged regional anesthesia or analgesia without systemic administration.
Approved indications
- Local anesthesia via indwelling catheter for perioperative pain management
- Regional anesthesia for surgical procedures
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures)
- Systemic toxicity (cardiac effects: arrhythmias, hypotension)
- Local tissue irritation or inflammation
- Allergic reactions
Key clinical trials
- EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement (PHASE2)
- Continuous vs Liposomal Bupivacaine Interscalene Block for Proximal Humeral Fracture (CLIP) (PHASE4)
- Exparel Interscalene vs Indwelling Catheter (PHASE2)
- Effects of Continuous Versus Single Dose Spinal Anesthesia in Octagenerians Undergoing Hip Surgery (NA)
- Fractional Spinal Anesthesia and Systemic Hemodynamics in Frail Elderly Hip Fracture Patients. (NA)
- Continuous Interscalene Block vs Liposomal Bupivacaine After Proximal Humerus Fracture Surgery (PHASE3)
- Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures (PHASE4)
- Effective Pain Management During Shoulder Replacement Surgery With EXPAREL (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine indwelling catheter CI brief — competitive landscape report
- Bupivacaine indwelling catheter updates RSS · CI watch RSS
- Denver Health and Hospital Authority portfolio CI