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Marcaine Injectable Product
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve block, epidural, and spinal anesthesia, Pain management during surgical and dental procedures.
At a glance
| Generic name | Marcaine Injectable Product |
|---|---|
| Also known as | Sensorcaine Injectable Product |
| Sponsor | University of California, Davis |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and action potential propagation. This results in local anesthesia and loss of sensation in the area where it is injected. The drug has a long duration of action due to its high lipophilicity and protein binding.
Approved indications
- Local anesthesia for infiltration, nerve block, epidural, and spinal anesthesia
- Pain management during surgical and dental procedures
Common side effects
- Hypotension
- Bradycardia
- Dizziness
- Nervousness
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients" (NA)
- Arthrosemid vs. Steroid for the Management Knee Osteoarthritis (PHASE4)
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA (NA)
- Postop Pain Management in Pituitary Tumour Patients (PHASE4)
- EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement (PHASE2)
- Efficacy of Nerve Blocks for Episodic Migraine (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Marcaine Injectable Product CI brief — competitive landscape report
- Marcaine Injectable Product updates RSS · CI watch RSS
- University of California, Davis portfolio CI