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Bupivacaine Injection [Marcaine]

South Egypt Cancer Institute · FDA-approved active Small molecule

Bupivacaine Injection [Marcaine] is a Local anesthetic Small molecule drug developed by South Egypt Cancer Institute. It is currently FDA-approved for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.

Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.

Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.

At a glance

Generic nameBupivacaine Injection [Marcaine]
SponsorSouth Egypt Cancer Institute
Drug classLocal anesthetic
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaAnesthesia
PhaseFDA-approved

Mechanism of action

Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and action potential propagation. This results in a loss of sensation in the injected area while preserving motor function at lower concentrations. The drug has a long duration of action (4–8 hours) due to its high lipophilicity and protein binding.

Approved indications

Common side effects

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Frequently asked questions about Bupivacaine Injection [Marcaine]

What is Bupivacaine Injection [Marcaine]?

Bupivacaine Injection [Marcaine] is a Local anesthetic drug developed by South Egypt Cancer Institute, indicated for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.

How does Bupivacaine Injection [Marcaine] work?

Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.

What is Bupivacaine Injection [Marcaine] used for?

Bupivacaine Injection [Marcaine] is indicated for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks, Epidural and spinal anesthesia.

Who makes Bupivacaine Injection [Marcaine]?

Bupivacaine Injection [Marcaine] is developed and marketed by South Egypt Cancer Institute (see full South Egypt Cancer Institute pipeline at /company/south-egypt-cancer-institute).

What drug class is Bupivacaine Injection [Marcaine] in?

Bupivacaine Injection [Marcaine] belongs to the Local anesthetic class. See all Local anesthetic drugs at /class/local-anesthetic.

What development phase is Bupivacaine Injection [Marcaine] in?

Bupivacaine Injection [Marcaine] is FDA-approved (marketed).

What are the side effects of Bupivacaine Injection [Marcaine]?

Common side effects of Bupivacaine Injection [Marcaine] include Systemic toxicity (CNS effects: tremor, seizures, loss of consciousness), Cardiovascular effects (hypotension, bradycardia, arrhythmias), Local reactions (pain, erythema at injection site), Allergic reactions.

What does Bupivacaine Injection [Marcaine] target?

Bupivacaine Injection [Marcaine] targets Voltage-gated sodium channels and is a Local anesthetic.

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