Last reviewed · How we verify

Bupivacaine Hcl 0.5% Inj

Hospital for Special Surgery Florida · FDA-approved active Small molecule

Bupivacaine Hcl 0.5% Inj is a Local anesthetic Small molecule drug developed by Hospital for Special Surgery Florida. It is currently FDA-approved for Local anesthesia for infiltration, nerve block, and regional anesthesia procedures, Epidural and spinal anesthesia. Also known as: Marcaine, Spinal anesthesia with epidural patient-controlled analgesia.

Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.

Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve block, and regional anesthesia procedures, Epidural and spinal anesthesia.

At a glance

Generic nameBupivacaine Hcl 0.5% Inj
Also known asMarcaine, Spinal anesthesia with epidural patient-controlled analgesia
SponsorHospital for Special Surgery Florida
Drug classLocal anesthetic
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaAnesthesia
PhaseFDA-approved

Mechanism of action

Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and action potential propagation. This results in local anesthesia and loss of sensation in the infiltrated tissue. The drug is long-acting due to its high lipophilicity and protein binding, allowing sustained nerve blockade.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Frequently asked questions about Bupivacaine Hcl 0.5% Inj

What is Bupivacaine Hcl 0.5% Inj?

Bupivacaine Hcl 0.5% Inj is a Local anesthetic drug developed by Hospital for Special Surgery Florida, indicated for Local anesthesia for infiltration, nerve block, and regional anesthesia procedures, Epidural and spinal anesthesia.

How does Bupivacaine Hcl 0.5% Inj work?

Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.

What is Bupivacaine Hcl 0.5% Inj used for?

Bupivacaine Hcl 0.5% Inj is indicated for Local anesthesia for infiltration, nerve block, and regional anesthesia procedures, Epidural and spinal anesthesia.

Who makes Bupivacaine Hcl 0.5% Inj?

Bupivacaine Hcl 0.5% Inj is developed and marketed by Hospital for Special Surgery Florida (see full Hospital for Special Surgery Florida pipeline at /company/hospital-for-special-surgery-florida).

Is Bupivacaine Hcl 0.5% Inj also known as anything else?

Bupivacaine Hcl 0.5% Inj is also known as Marcaine, Spinal anesthesia with epidural patient-controlled analgesia.

What drug class is Bupivacaine Hcl 0.5% Inj in?

Bupivacaine Hcl 0.5% Inj belongs to the Local anesthetic class. See all Local anesthetic drugs at /class/local-anesthetic.

What development phase is Bupivacaine Hcl 0.5% Inj in?

Bupivacaine Hcl 0.5% Inj is FDA-approved (marketed).

What are the side effects of Bupivacaine Hcl 0.5% Inj?

Common side effects of Bupivacaine Hcl 0.5% Inj include Systemic toxicity (CNS effects: tremor, seizures), Cardiovascular effects (hypotension, arrhythmias), Local tissue irritation or pain at injection site, Allergic reactions.

What does Bupivacaine Hcl 0.5% Inj target?

Bupivacaine Hcl 0.5% Inj targets Voltage-gated sodium channels and is a Local anesthetic.

Related