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Local Anesthesia

University of Maryland, Baltimore · Phase 3 active Small molecule

Local anesthetics block sodium channels in nerve cell membranes to prevent the initiation and conduction of nerve impulses, thereby producing localized numbness and pain relief.

Local anesthetics block sodium channels in nerve cell membranes to prevent the initiation and conduction of nerve impulses, thereby producing localized numbness and pain relief. Used for Local anesthesia for surgical and procedural pain management.

At a glance

Generic nameLocal Anesthesia
Also known asAmniocentesis, Lidocaine hydrochloride, Esracain injection 2%
SponsorUniversity of Maryland, Baltimore
Drug classLocal anesthetic
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaAnesthesia
PhasePhase 3

Mechanism of action

Local anesthetics work by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, which prevents depolarization and action potential generation. This effect is localized to the area of administration, allowing pain sensation to be blocked while preserving motor and other sensory functions depending on the concentration and nerve fiber type affected. The drug is typically administered directly at or near the site requiring anesthesia.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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