{"id":"local-anesthesia","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS effects: tremor, seizures)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, arrhythmias)"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Methemoglobinemia (benzocaine)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Local anesthetics work by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, which prevents depolarization and action potential generation. This effect is localized to the area of administration, allowing pain sensation to be blocked while preserving motor and other sensory functions depending on the concentration and nerve fiber type affected. The drug is typically administered directly at or near the site requiring anesthesia.","oneSentence":"Local anesthetics block sodium channels in nerve cell membranes to prevent the initiation and conduction of nerve impulses, thereby producing localized numbness and pain relief.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:19:16.171Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for surgical and procedural pain management"}]},"trialDetails":[{"nctId":"NCT07497009","phase":"NA","title":"Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial.","status":"COMPLETED","sponsor":"Benha University","startDate":"2024-12-23","conditions":"Neurocognitive Function of Elderly Patients Post Operation","enrollment":30},{"nctId":"NCT05933954","phase":"NA","title":"The Effects of 5G Radiation on Skin","status":"RECRUITING","sponsor":"Prof. Olivier Gaide, MD-PhD","startDate":"2024-01-09","conditions":"Electromagnetic Radiation (5GFR2)","enrollment":42},{"nctId":"NCT07496632","phase":"NA","title":"Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients\"","status":"NOT_YET_RECRUITING","sponsor":"Bangladesh Medical University","startDate":"2026-04","conditions":"Scalp Block","enrollment":72},{"nctId":"NCT06890026","phase":"","title":"Durability of Three Monthly Loading Doses With Faricimab in Treatment-naïve Neovascular Age-related Macular Degeneration","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2024-11-15","conditions":"Neovascular Age-Related Macular Degeneration (nAMD), Treatment-naïve","enrollment":742},{"nctId":"NCT06807164","phase":"PHASE2","title":"Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome","status":"RECRUITING","sponsor":"Centre Oscar Lambret","startDate":"2026-03-31","conditions":"Post-Mastectomy Neuropathic Pain Syndrome","enrollment":123},{"nctId":"NCT07494383","phase":"NA","title":"Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial","status":"COMPLETED","sponsor":"ISSSTE Hospital Regional \"Gral. 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