Last reviewed 2026-04-23 · How we verify

Chloroprocaine 2% Injectable Solution

Local anesthetic by blocking sodium channels

Local anesthetic by blocking sodium channels Used for Spinal anesthesia.

At a glance

Mechanism of action

Chloroprocaine works by inhibiting the influx of sodium ions through voltage-gated sodium channels, which helps to block the initiation and transmission of nerve impulses.

Approved indications

• Spinal anesthesia

Common side effects

• Nausea
• Vomiting
• Hypotension

Key clinical trials

• The Efficacy and Safety of Chloroprocaine 1% and 2% in Pediatric Population (PHASE2)
• Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections (PHASE4)
• Chloroprocaine 3% - Epidural Anesthesia in Unplanned Caesarean Section (PHASE3)
• Chloroprocaine 2% vs Ropivacaine 0.75% in Ultrasound-guided Axillary Nerve Block (PHASE3)
• Intrathecal Paracetamol Before Spinal Anaesthesia With Chloroprocaine HCl 1% for Short Knee Procedures (PHASE2)
• Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) (PHASE4)
• Chloroprocaine for Inguinal Herniorrhaphy (PHASE4)

Primary sources

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Competitive intelligence

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• Chloroprocaine 2% Injectable Solution CI brief — competitive landscape report
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• Sintetica SA portfolio CI