Sodium channels — Drug Target

All drugs that target Sodium channels — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Local anesthetic · Osmotic Diuretic [EPC] · Class III antiarrhythmic

Marketed (4)

• Bupivacaine Hydrochloride And Epinephrine · Pfizer · Local anesthetic
  Bupivacaine blocks nerve impulses by increasing the threshold for electrical excitation, slowing nerve impulse propagation, and reducing the rate of rise of the action potential.
• Lidocaine patch local application · Taipei Medical University Hospital · Local anesthetic · Pain
  Lidocaine patch works by locally blocking sodium channels in nerve cells, which reduces the transmission of pain signals.
• MEXILETINE HYDROCHLORIDE
  Mexiletine, an oral antiarrhythmic, reduces ventricular arrhythmias by inhibiting sodium currents and altering refractory periods.
• Aridol Kit · Baxter · Osmotic Diuretic [EPC] · Immunology
  Mannitol works by drawing water into the bloodstream from surrounding tissues, increasing urine production and reducing fluid accumulation in the body.

Phase 3 pipeline (5)

• topical amiodarone · Jilin Heart Hospital · Class III antiarrhythmic · Cardiovascular
  Topical amiodarone works by blocking sodium channels in the heart to prevent abnormal heart rhythms.
• TCA IR 40 · Pacira Pharmaceuticals, Inc · Local anesthetic · Pain management
  TCA IR 40 is a local anesthetic that works by blocking nerve signals.
• Oxybuprocaine/fluorescein SDU · Medical University of Vienna · Local anesthetic · Ophthalmology
  Oxybuprocaine/fluorescein SDU is a local anesthetic and a fluorescent dye used to visualize the corneal endothelium.
• botulinum toxin A + ropivacaïne · Nantes University Hospital · Local anesthetic · Pain management
  Botulinum toxin A blocks the release of acetylcholine, a neurotransmitter that causes muscle contraction, while ropivacaine is a local anesthetic that blocks sodium channels to prevent nerve impulses.
• Oxybuprocaine MDU · Medical University of Vienna · Local anesthetic · Ophthalmology
  Oxybuprocaine MDU is a local anesthetic that works by blocking sodium channels in nerve fibers, preventing the initiation and transmission of nerve impulses.

Phase 2 pipeline (1)

• DLX105 Hydrogel · Delenex Therapeutics AG · Local anesthetic · Pain management
  DLX105 Hydrogel is a hydrogel formulation of a local anesthetic.