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topical amiodarone
Topical amiodarone works by blocking sodium channels in the heart to prevent abnormal heart rhythms.
Topical amiodarone works by blocking sodium channels in the heart to prevent abnormal heart rhythms. Used for Atrial fibrillation for stroke prevention, Ventricular tachycardia.
At a glance
| Generic name | topical amiodarone |
|---|---|
| Sponsor | Jilin Heart Hospital |
| Drug class | Class III antiarrhythmic |
| Target | Sodium channels |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
This action helps to stabilize the heart's electrical activity and prevent arrhythmias. Topical amiodarone is a class III antiarrhythmic agent that prolongs the action potential duration and refractory period in cardiac cells.
Approved indications
- Atrial fibrillation for stroke prevention
- Ventricular tachycardia
Common side effects
- Skin rash
- Pruritus
- Hypotension
Key clinical trials
- BiodEgradable Soaked Amiodarone paTch Use for the Prevention of Atrial Fibrillation After Cardiac Surgery (PHASE3)
- Amiodarone-Infused CardiaMend Patches for the Prevention of New-Onset POAF in Cardiac Surgery Subjects (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |