{"id":"topical-amiodarone","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Skin rash"},{"rate":"5-10%","effect":"Pruritus"},{"rate":"5-10%","effect":"Hypotension"}]},"_chembl":{"chemblId":"CHEMBL1083993","moleculeType":"Small molecule","molecularWeight":"681.78"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This action helps to stabilize the heart's electrical activity and prevent arrhythmias. Topical amiodarone is a class III antiarrhythmic agent that prolongs the action potential duration and refractory period in cardiac cells.","oneSentence":"Topical amiodarone works by blocking sodium channels in the heart to prevent abnormal heart rhythms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:39:19.826Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atrial fibrillation for stroke prevention"},{"name":"Ventricular tachycardia"}]},"trialDetails":[{"nctId":"NCT06722196","phase":"PHASE3","title":"BiodEgradable Soaked Amiodarone paTch Use for the Prevention of Atrial Fibrillation After Cardiac Surgery","status":"RECRUITING","sponsor":"Jilin Heart Hospital","startDate":"2025-02-15","conditions":"Atrial Fibrillation (AF)","enrollment":500},{"nctId":"NCT06730828","phase":"PHASE1, PHASE2","title":"Amiodarone-Infused CardiaMend Patches for the Prevention of New-Onset POAF in Cardiac Surgery Subjects","status":"RECRUITING","sponsor":"Helios Cardio Inc.","startDate":"2024-12-16","conditions":"Atrial Fibrillation, Postoperative","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"topical amiodarone","genericName":"topical amiodarone","companyName":"Jilin Heart Hospital","companyId":"jilin-heart-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Topical amiodarone works by blocking sodium channels in the heart to prevent abnormal heart rhythms. Used for Atrial fibrillation for stroke prevention, Ventricular tachycardia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}