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Nerve block with Lidocain
Lidocaine blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce local anesthesia.
Lidocaine blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce local anesthesia. Used for Local and regional anesthesia via nerve block, Pain management in surgical and procedural settings.
At a glance
| Generic name | Nerve block with Lidocain |
|---|---|
| Sponsor | Tehran University of Medical Sciences |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in nerve cell membranes. This prevents depolarization and action potential generation in sensory and motor nerves. When administered as a nerve block, it reversibly interrupts nerve conduction in a specific anatomical region, providing localized anesthesia without systemic effects.
Approved indications
- Local and regional anesthesia via nerve block
- Pain management in surgical and procedural settings
Common side effects
- Injection site reactions (pain, erythema)
- Transient paresthesia
- Systemic toxicity (if absorbed in high amounts)
- Allergic reactions (rare with amide lidocaine)
Key clinical trials
- Percutaneous Electrical Nerve Stimulation As Alternative To Nerve Blocks In Anesthesia, Pain Medicine And Rehabilitation Of Nonspecific Chronic Pain (PHASE4)
- Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block (NA)
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
- Role of Nerve Block in Management of Multiple Rib Fractures (PHASE4)
- The Use of Infiltrative Anesthesia Instead of Inferior Alveolar Block (PHASE4)
- Comparison of the Efficacy of Phenol Block and Corticosteroid-Local Anesthetic Block Applied to the Genicular Nerve (NA)
- Femoral Nerve Blockade in Endovenous Laser (NA)
- PENG Versus Femoral Nerve Block in Neck of Femur Fracture (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Nerve block with Lidocain CI brief — competitive landscape report
- Nerve block with Lidocain updates RSS · CI watch RSS
- Tehran University of Medical Sciences portfolio CI