{"id":"nerve-block-with-lidocain","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions (pain, erythema)"},{"rate":null,"effect":"Transient paresthesia"},{"rate":null,"effect":"Systemic toxicity (if absorbed in high amounts)"},{"rate":"<1","effect":"Allergic reactions (rare with amide lidocaine)"}]},"_chembl":{"chemblId":"CHEMBL4297796","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in nerve cell membranes. This prevents depolarization and action potential generation in sensory and motor nerves. When administered as a nerve block, it reversibly interrupts nerve conduction in a specific anatomical region, providing localized anesthesia without systemic effects.","oneSentence":"Lidocaine blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce local anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:01.676Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia via nerve block"},{"name":"Pain management in surgical and procedural settings"}]},"trialDetails":[{"nctId":"NCT07273006","phase":"PHASE4","title":"Percutaneous Electrical Nerve Stimulation As Alternative To Nerve Blocks In Anesthesia, Pain Medicine And Rehabilitation Of Nonspecific Chronic Pain","status":"NOT_YET_RECRUITING","sponsor":"Universidad Complutense de Madrid","startDate":"2026-09-01","conditions":"Non-specific Low Back Pain (NSLBP), Facet Joint Syndrome","enrollment":82},{"nctId":"NCT05372393","phase":"NA","title":"Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block","status":"RECRUITING","sponsor":"Kuopio University Hospital","startDate":"2022-09-21","conditions":"Carpal Tunnel Syndrome","enrollment":118},{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT06958549","phase":"PHASE4","title":"Role of Nerve Block in Management of Multiple Rib Fractures","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-12","conditions":"Multiple Rib Fractures","enrollment":74},{"nctId":"NCT06439186","phase":"PHASE4","title":"The Use of Infiltrative Anesthesia Instead of Inferior Alveolar Block","status":"COMPLETED","sponsor":"Konya Necmettin Erbakan Üniversitesi","startDate":"2022-05-01","conditions":"Local Infiltration","enrollment":60},{"nctId":"NCT06265675","phase":"NA","title":"Comparison of the Efficacy of Phenol Block and Corticosteroid-Local Anesthetic Block Applied to the Genicular Nerve","status":"UNKNOWN","sponsor":"Gaziler Physical Medicine and Rehabilitation Education and Research Hospital","startDate":"2024-01-24","conditions":"Knee Osteoarthritis","enrollment":88},{"nctId":"NCT03475641","phase":"NA","title":"Femoral Nerve Blockade in Endovenous Laser","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2017-03-13","conditions":"Pain","enrollment":80},{"nctId":"NCT05002725","phase":"NA","title":"PENG Versus Femoral Nerve Block in Neck of Femur Fracture","status":"UNKNOWN","sponsor":"University College Cork","startDate":"2021-01-28","conditions":"Neck of Femur Fracture","enrollment":64},{"nctId":"NCT03454789","phase":"NA","title":"Comparison of the Onset Times and Durations of Actions of Different Local Anesthetic Mixture Solutions [CODLAM]","status":"COMPLETED","sponsor":"University of Pecs","startDate":"2017-01-17","conditions":"Injury Arm","enrollment":85},{"nctId":"NCT01768377","phase":"PHASE3","title":"Comparison of Intubation With Nerve Block and With Sedation in Awake Patients","status":"UNKNOWN","sponsor":"Tehran University of Medical Sciences","startDate":"2012-11","conditions":"Intubation Complication","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Nerve block with Lidocain","genericName":"Nerve block with Lidocain","companyName":"Tehran University of Medical Sciences","companyId":"tehran-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce local anesthesia. Used for Local and regional anesthesia via nerve block, Pain management in surgical and procedural settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}