Last reviewed · How we verify
Bupivacaine low dose
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local anesthesia for surgical and diagnostic procedures, Regional anesthesia (nerve blocks, epidural, spinal anesthesia).
At a glance
| Generic name | Bupivacaine low dose |
|---|---|
| Sponsor | Fundacion para la Investigacion Biomedica del Hospital Universitario Principe de Asturias |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, inhibiting sodium influx and preventing depolarization. This action halts the generation and conduction of nerve impulses in the area where it is administered. The low-dose formulation is designed to minimize systemic toxicity while maintaining local anesthetic efficacy.
Approved indications
- Local anesthesia for surgical and diagnostic procedures
- Regional anesthesia (nerve blocks, epidural, spinal anesthesia)
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Local tissue irritation or injection site reactions
- Allergic reactions
Key clinical trials
- A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery (PHASE2)
- Epidural vs. Dural Puncture Epidural in Labor Analgesia (NA)
- Pain Relief Comparison: Pericapsular Nerve Group Versus Quadratus Lumborum Block for Positioning in Femur Fracture Surgery (NA)
- Lumbar-Sacral Plexus Block vs Fascia Iliaca Block Plus Low-Dose Spinal Anesthesia for Femoral Neck Fracture Surgery (NA)
- Adductor Canal Block and IPACK Block vs Adductor Canal Block and the Gastrosoleus Interfascial Block After Total Knee Arthroplasty (NA)
- Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy. (NA)
- Comparative Dose-Response of Intrathecal Dexmedetomidine for Post-Spinal Shivering (PHASE3)
- Regional Anesthesia in Ambulatory Endovenous Ablation Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: