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Intra-articular Lidocaine
Intra-articular Lidocaine is a Local anesthetic Small molecule drug developed by University of Central Florida. It is currently FDA-approved for Intra-articular pain relief in joint disorders, Post-operative joint pain management.
Lidocaine blocks sodium channels in nerve fibers to provide local anesthesia and pain relief when injected directly into the joint space.
Lidocaine blocks sodium channels in nerve fibers to provide local anesthesia and pain relief when injected directly into the joint space. Used for Intra-articular pain relief in joint disorders, Post-operative joint pain management.
At a glance
| Generic name | Intra-articular Lidocaine |
|---|---|
| Sponsor | University of Central Florida |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Pain management / Orthopedics |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in nerve cell membranes, thereby preventing depolarization and blocking pain signal transmission. When administered intra-articularly, it provides localized anesthesia and analgesia directly at the site of joint pain, reducing pain perception without systemic effects.
Approved indications
- Intra-articular pain relief in joint disorders
- Post-operative joint pain management
Common side effects
- Local injection site reactions
- Transient numbness or tingling
- Allergic reactions (rare with amide lidocaine)
Key clinical trials
- OMT for Adhesive Capsulitis (PHASE4)
- Efficacy of Autologous Conditioned Serum in Temporomandibular Joint Disorder (NA)
- Synovial Tissue as a Biomarker in the Early Management of Osteoarthritis (NA)
- Combination of Fluoroscopy and Ultrasonography Guidance in Sacroiliac Joint Injections. A Randomised Controlled Trial (NA)
- Knee Injections for Obese Patients With Knee Arthritis (PHASE4)
- A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses Standard of Care in Adhesive Capsulitis of the Shoulder (PHASE4)
- Low-Cost Platelet-Rich Plasma for Hemarthropathy (NA)
- Pericapsular Nerve Group Block Added to Intra-articular Corticosteroid Injection in the Treatment of Hip Pain
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intra-articular Lidocaine CI brief — competitive landscape report
- Intra-articular Lidocaine updates RSS · CI watch RSS
- University of Central Florida portfolio CI
Frequently asked questions about Intra-articular Lidocaine
What is Intra-articular Lidocaine?
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Related
- Drug class: All Local anesthetic drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: University of Central Florida — full pipeline
- Therapeutic area: All drugs in Pain management / Orthopedics
- Indication: Drugs for Intra-articular pain relief in joint disorders
- Indication: Drugs for Post-operative joint pain management
- Compare: Intra-articular Lidocaine vs similar drugs
- Pricing: Intra-articular Lidocaine cost, discount & access