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Locoregional anesthesia

Hospices Civils de Lyon · Phase 3 active Small molecule

Locoregional anesthesia blocks nerve conduction locally to produce reversible loss of sensation in a specific anatomical region without affecting consciousness.

Locoregional anesthesia blocks nerve conduction locally to produce reversible loss of sensation in a specific anatomical region without affecting consciousness. Used for Local or regional anesthesia for surgical procedures, Pain management and analgesia in clinical settings.

At a glance

Generic nameLocoregional anesthesia
SponsorHospices Civils de Lyon
Drug classLocal anesthetic
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaAnesthesia / Pain Management
PhasePhase 3

Mechanism of action

Locoregional anesthesia works by infiltrating local anesthetic agents (such as lidocaine or bupivacaine) into tissues or near nerves to inhibit sodium channel activity and prevent action potential propagation. This produces anesthesia confined to the targeted area while preserving consciousness and airway reflexes. It is commonly used for surgical procedures, pain management, and diagnostic interventions where general anesthesia is not required or desired.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results