Hospices Civils de Lyon

Quick facts

Marketed products

• Antifungal treatment · Infectious Disease
  Antifungal treatments work by disrupting fungal cell wall or membrane integrity, or inhibiting essential fungal enzymes, thereby killing or stopping the growth of fungal organisms.
• blood sample
  A blood sample is a diagnostic specimen collected for laboratory analysis to assess health status, detect diseases, or monitor treatment.
• Cabozantinib group
• CLARA · Other
• DARATUMUMAB (DARZALEX®) · Oncology
  Daratumumab is a monoclonal antibody that binds to CD38 on the surface of multiple myeloma cells, triggering their destruction through multiple immune mechanisms.
• Indapamide (T2) · Cardiovascular
  Indapamide is a thiazide-like diuretic that inhibits sodium reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure.
• parenteral nutrition · Nutritional support / Critical care
  Parenteral nutrition delivers a balanced mixture of carbohydrates, proteins, lipids, vitamins, and minerals intravenously to provide complete nutritional support when oral or enteral feeding is not possible.
• Perindopril (T1) · Cardiovascular
  Perindopril inhibits angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II and lowering blood pressure.
• Pharmacokinetics, Dosage of Niraparib · Oncology
  Niraparib inhibits poly(ADP-ribose) polymerase (PARP) enzymes, preventing DNA repair in cancer cells and leading to cell death.
• pirfenidone and nintedanib
• pirfenidone or nintedanib · Pulmonary/Respiratory
  Pirfenidone and nintedanib are antifibrotic agents that reduce fibroblast proliferation and collagen deposition to slow lung fibrosis progression.
• Placebo of Indapamide (P2)
  This is a placebo control with no active pharmacological mechanism.
• Placebo of Perindopril (P1)
  This is a placebo formulation with no active pharmacological mechanism.
• PRIVIGEN (CSL Behring) · Immunology
  PRIVIGEN is an intravenous immunoglobulin (IVIg) that provides passive immunity by supplying pooled human antibodies to modulate immune responses and replace deficient immunoglobulins.
• tocopherol alpha

Phase 3 pipeline

• ciclosporine · Immunology
• Corticosteroid boluses Methylprednisolone · Immunology / Rheumatology / Neurology
  Methylprednisolone is a synthetic corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
• Daily dose of cholecalciferol per os · Bone health, Immunology, Endocrinology
  Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.
• Glucose 5% (placebo)
  Glucose 5% solution serves as an inert placebo control with no active pharmacological mechanism.
• Injection of Cyclosporin · Immunology
  Cyclosporin is a calcineurin inhibitor that suppresses T-cell activation by blocking the transcription of pro-inflammatory cytokines.
• keto-analogs · Diabetes
  Keto-analogs are synthetic compounds that mimic the effects of ketone bodies, which are produced by the liver when it breaks down fat for energy.
• Lévétiracetam · Neurology
  Levetiracetam reduces neuronal excitability by binding to synaptic vesicle protein SV2A, thereby modulating neurotransmitter release and preventing seizure propagation.
• Locoregional anesthesia · Anesthesia / Pain Management
  Locoregional anesthesia blocks nerve conduction locally to produce reversible loss of sensation in a specific anatomical region without affecting consciousness.
• Midazolam oral intake · Psychiatry/Neurology
  Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation and anxiolysis.
• Monthly bolus of cholecalciferol per os · Endocrinology / Bone metabolism / Immunology
  Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.
• PCV chemotherapy · Oncology
  PCV is a chemotherapy regimen combining procarbazine, lomustine (CCNU), and vincristine to disrupt cancer cell DNA and microtubule function.
• Peg-interferon alpha 2a and ribavin · Virology/Hepatology
  Peg-interferon alpha-2a activates innate immune responses against viral infection, while ribavirin inhibits viral RNA synthesis, together targeting hepatitis C virus replication.
• peroperative infiltration of local anesthetics
• Placebo followed by zicotinide · Pain Management
  Ziconotide is a selective N-type calcium channel blocker that reduces neuronal excitability and neurotransmitter release in the spinal cord to alleviate chronic pain.
• PSA dosage · Oncology
  PSA dosage is used to measure the level of prostate-specific antigen in the blood, which can help diagnose and monitor prostate cancer.
• Radiotherapy and PCV chemotherapy · Oncology
  This combination uses ionizing radiation to destroy tumor cells directly while chemotherapy with procarbazine, lomustine, and vincristine (PCV) enhances cell death through DNA damage and mitotic inhibition.
• ribavirin with adaptation dose · Infectious Diseases
  Ribavirin is an antiviral medication that works by inhibiting viral RNA synthesis.
• somatostatin infusion · Gastroenterology
  Somatostatin infusion activates somatostatin receptors on neuroendocrine and immune cells to inhibit hormone and cytokine secretion and reduce splanchnic blood flow.
• Tocofersolan and tocopherol alpha · Cardiovascular
  Tocofersolan and tocopherol alpha work together to provide antioxidant properties.
• Vayarin®, supplementation of n-3 PUFA · Neurology
  Vayarin® provides a targeted delivery of n-3 polyunsaturated fatty acids (PUFAs) to support brain health and function.

Phase 2 pipeline

• Administration of a PET radiotracer · Nuclear Medicine
  This PET radiotracer is used to visualize and diagnose various diseases by emitting radiation that can be detected by a PET scanner.
• analysis of foecal microbiota
• Biocollection · Other
• Biological analyses · Oncology
  This drug targets the PD-1 receptor to modulate the immune system.
• Biological analysis · Oncology
  This drug targets the PD-1 receptor to modulate the immune response.
• Biological samplings · Oncology
  Biological samplings involve the collection and analysis of biological samples to understand disease mechanisms and monitor treatment response.
• blood sample - Bacteraemia group
• blood samplings
• Blood taken · General Health
  Blood taken is used to diagnose and monitor various health conditions.
• BPAN Patients · Genetics
  BPAN Patients is a treatment for a rare genetic disorder.
• Carboplatin monotherapy every 3 weeks
• Carboplatin-Taxol-Radiotherapy · Oncology
  Carboplatin is a platinum-based chemotherapy drug that interferes with DNA replication, while Taxol (paclitaxel) is a microtubule inhibitor that prevents cell division. Radiotherapy uses ionizing radiation to kill cancer cells.
• cccDNA assay on liver biopsy
• CELSIOR® group · Diabetes
  CELSEOR is a glucagon receptor agonist.
• CFTR modulators · Respiratory
  CFTR modulators work by modifying the cystic fibrosis transmembrane conductance regulator protein to restore normal chloride ion transport across epithelial cell membranes.
• Ciclosprin A · Immunology
  Ciclosprin A is an immunosuppressive agent that inhibits the activity of T cells.
• Cisplatin-Gemzar · Oncology
  Cisplatin-Gemzar works by inhibiting DNA replication and interfering with the synthesis of DNA and RNA, ultimately leading to cell death.
• Cisplatin-Navelbine-Radiotherapy · Oncology
  Cisplatin works by crosslinking DNA, causing cell death, while Navelbine inhibits microtubule formation, disrupting cell division.
• CTC detection · Oncology
  CTC detection is a diagnostic technology that identifies and isolates circulating tumor cells (CTCs) from patient blood samples to enable cancer monitoring and prognosis assessment.
• ctDNA analysis
• Culture of removed prosthesis using DTT · Infectious Disease / Orthopedic Surgery
  This is a diagnostic/microbiological procedure that cultures removed prosthetic material treated with dithiothreitol (DTT) to identify bacterial biofilms and infections.
• DAA treatment
• Direct-acting antiviral therapy · Infectious Disease
  Direct-acting antiviral therapy targets viral replication by inhibiting viral enzymes.
• Echinocandin treatment
• Genetic and immunology tests
• Gutron® treatment · Cardiovascular
  Gutron treatment works by inhibiting the reabsorption of bile acids in the ileum.
• HDAc
• Incidence of acute kidney injury
• Intravenous human immunoglobulin
• lymphocytes immunophenotyping
• Medialipide 20% perfusion
• Nephrocheck test
• Oxaluria evolution.
• Plasma Sample
• R-ACVBP14 induction regimen
• R-CHOP14 induction regimen
• Registry · Other
• Relaxine dosage
• Saint-Thomas group
• Saliva sampling

Phase 1 pipeline

• [11C]Yohimbine
• [18F]F13640
• A nasal swab
• Alkylating-based chemotherapy · Oncology
  Alkylating agent that interferes with DNA replication
• Application of Onco-Neutre cream
• Application of Onco-Rash cream
• Arterial blood sampling
• Axillary block anesthesia with Ropivacaine and Lidocaine
• Blood and biopsy sampling
• Blood samples Donnor
• Blood test at D0
• Bone marrow sampling
• Collection of a lock of hair
• Cord blood sampling
• Cord sampling
• Creation of a serum biobank
• Diagnostic performances of biomarkers combination
• euglycemic hyperinsulinemic clamp
• FEMJA transplatation
• Hepatitis E serology
• Ileocolonic biopsies
• Iohexol renal clearance measurement
• Low or upper respiratory tract sample
• Postoperative dosage of released troponin
• profile of CSF biomarkers of AD
• Skin auto-fluorescence
• Stool collection or fecal swab
• Stool simple
• TTV DNAemia
• Ultrafiltrate sampling
• Urinary dosage
• Urine and blood samples
• urine specimens

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Hospices Civils de Lyon portfolio CI brief
• Hospices Civils de Lyon pipeline updates RSS