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Monthly bolus of cholecalciferol per os
Monthly bolus of cholecalciferol per os is a Vitamin D supplement Small molecule drug developed by Hospices Civils de Lyon. It is currently in Phase 3 development for Vitamin D deficiency prevention and treatment, Bone health and osteoporosis prevention.
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function. Used for Vitamin D deficiency prevention and treatment, Bone health and osteoporosis prevention.
At a glance
| Generic name | Monthly bolus of cholecalciferol per os |
|---|---|
| Sponsor | Hospices Civils de Lyon |
| Drug class | Vitamin D supplement |
| Target | Vitamin D receptor (VDR) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Bone metabolism / Immunology |
| Phase | Phase 3 |
Mechanism of action
Cholecalciferol is a fat-soluble vitamin that undergoes hydroxylation in the liver and kidneys to form the active hormone calcitriol (1,25-dihydroxyvitamin D3). This active metabolite binds to the vitamin D receptor (VDR) in target tissues, promoting intestinal calcium and phosphate absorption, bone mineralization, and immune cell differentiation and function. Monthly bolus dosing provides sustained vitamin D status to address deficiency.
Approved indications
- Vitamin D deficiency prevention and treatment
- Bone health and osteoporosis prevention
Common side effects
- Hypercalcemia
- Hypercalciuria
- Nausea
- Constipation
Key clinical trials
- Daily Vitamin D for Sickle-cell Respiratory Complications (PHASE2)
- Monthly Boluses Versus Daily Doses for Correcting Blood Vitamin D Deficit in Obese Children and Adolescents (PHASE3)
- Vitamin D to Reduce Colds and Asthma Attacks in Young Children (PHASE2)
- Trial of Vitamin D Supplementation in Asthma (PHASE2, PHASE3)
- Trial of Vitamin D Supplementation in Chronic Obstructive Pulmonary Disease (PHASE2, PHASE3)
- Trial of Vitamin D Supplementation for the Prevention of Influenza and Other Respiratory Infections (ViDiFlu) (PHASE2, PHASE3)
- The Role of Vitamin D in Menopause: Relationship to Menopausal Symptoms in Body Composition (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Monthly bolus of cholecalciferol per os CI brief — competitive landscape report
- Monthly bolus of cholecalciferol per os updates RSS · CI watch RSS
- Hospices Civils de Lyon portfolio CI
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Related
- Drug class: All Vitamin D supplement drugs
- Target: All drugs targeting Vitamin D receptor (VDR)
- Manufacturer: Hospices Civils de Lyon — full pipeline
- Therapeutic area: All drugs in Endocrinology / Bone metabolism / Immunology
- Indication: Drugs for Vitamin D deficiency prevention and treatment
- Indication: Drugs for Bone health and osteoporosis prevention
- Compare: Monthly bolus of cholecalciferol per os vs similar drugs
- Pricing: Monthly bolus of cholecalciferol per os cost, discount & access