{"id":"monthly-bolus-of-cholecalciferol-per-os","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypercalcemia"},{"rate":null,"effect":"Hypercalciuria"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cholecalciferol is a fat-soluble vitamin that undergoes hydroxylation in the liver and kidneys to form the active hormone calcitriol (1,25-dihydroxyvitamin D3). This active metabolite binds to the vitamin D receptor (VDR) in target tissues, promoting intestinal calcium and phosphate absorption, bone mineralization, and immune cell differentiation and function. Monthly bolus dosing provides sustained vitamin D status to address deficiency.","oneSentence":"Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:22:06.168Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin D deficiency prevention and treatment"},{"name":"Bone health and osteoporosis prevention"}]},"trialDetails":[{"nctId":"NCT04170348","phase":"PHASE2","title":"Daily Vitamin D for Sickle-cell Respiratory Complications","status":"COMPLETED","sponsor":"Columbia University","startDate":"2020-09-15","conditions":"Sickle Cell Disease, Anemia, Sickle Cell, Anemia, Hemolytic, Congenital","enrollment":58},{"nctId":"NCT03516968","phase":"PHASE3","title":"Monthly Boluses Versus Daily Doses for Correcting Blood Vitamin D Deficit in Obese Children and Adolescents","status":"RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2023-12-04","conditions":"Obesity, Childhood","enrollment":68},{"nctId":"NCT01999907","phase":"PHASE2","title":"Vitamin D to Reduce Colds and Asthma Attacks in Young Children","status":"COMPLETED","sponsor":"St. Justine's Hospital","startDate":"2013-11","conditions":"Asthma","enrollment":22},{"nctId":"NCT00978315","phase":"PHASE2, PHASE3","title":"Trial of Vitamin D Supplementation in Asthma","status":"COMPLETED","sponsor":"Barts & The London NHS Trust","startDate":"2009-09","conditions":"Asthma","enrollment":250},{"nctId":"NCT00977873","phase":"PHASE2, PHASE3","title":"Trial of Vitamin D Supplementation in Chronic Obstructive Pulmonary Disease","status":"COMPLETED","sponsor":"Barts & The London NHS Trust","startDate":"2009-09","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":240},{"nctId":"NCT01069874","phase":"PHASE2, PHASE3","title":"Trial of Vitamin D Supplementation for the Prevention of Influenza and Other Respiratory Infections (ViDiFlu)","status":"COMPLETED","sponsor":"Barts & The London NHS Trust","startDate":"2010-03","conditions":"Respiratory Tract Infections, Influenza","enrollment":240},{"nctId":"NCT01141972","phase":"PHASE1","title":"The Role of Vitamin D in Menopause: Relationship to Menopausal Symptoms in Body Composition","status":"COMPLETED","sponsor":"Kaiser Permanente","startDate":"2010-09","conditions":"Hot Flushes, Menopause, Premature, Obesity","enrollment":23}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Monthly bolus of cholecalciferol per os","genericName":"Monthly bolus of cholecalciferol per os","companyName":"Hospices Civils de Lyon","companyId":"hospices-civils-de-lyon","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function. Used for Vitamin D deficiency prevention and treatment, Bone health and osteoporosis prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}