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Culture of removed prosthesis using DTT
This is a diagnostic/microbiological procedure that cultures removed prosthetic material treated with dithiothreitol (DTT) to identify bacterial biofilms and infections.
This is a diagnostic/microbiological procedure that cultures removed prosthetic material treated with dithiothreitol (DTT) to identify bacterial biofilms and infections. Used for Diagnosis of prosthetic joint infection (PJI), Identification of biofilm-associated infections on removed prosthetic devices.
At a glance
| Generic name | Culture of removed prosthesis using DTT |
|---|---|
| Sponsor | Hospices Civils de Lyon |
| Modality | Biologic |
| Therapeutic area | Infectious Disease / Orthopedic Surgery |
| Phase | Phase 2 |
Mechanism of action
DTT is a reducing agent that breaks disulfide bonds in bacterial biofilm matrices, enhancing the recovery and identification of microorganisms from explanted prosthetic devices. This technique is used to diagnose prosthetic joint infections and other device-related infections by improving bacterial culture yield from biofilm-embedded organisms that would otherwise be missed by standard culture methods.
Approved indications
- Diagnosis of prosthetic joint infection (PJI)
- Identification of biofilm-associated infections on removed prosthetic devices
Common side effects
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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