{"id":"culture-of-removed-prosthesis-using-dtt","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL47903","moleculeType":"Small molecule","molecularWeight":"154.26"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"DTT is a reducing agent that breaks disulfide bonds in bacterial biofilm matrices, enhancing the recovery and identification of microorganisms from explanted prosthetic devices. This technique is used to diagnose prosthetic joint infections and other device-related infections by improving bacterial culture yield from biofilm-embedded organisms that would otherwise be missed by standard culture methods.","oneSentence":"This is a diagnostic/microbiological procedure that cultures removed prosthetic material treated with dithiothreitol (DTT) to identify bacterial biofilms and infections.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T03:29:56.464Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Diagnosis of prosthetic joint infection (PJI)"},{"name":"Identification of biofilm-associated infections on removed prosthetic devices"}]},"trialDetails":[{"nctId":"NCT04371068","phase":"","title":"Heraeus MicroDTTect Lyon Pilot Studyprosthetic Joint Infections (PJIs)","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2018-03-01","conditions":"Chronic PJIs","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Culture of removed prosthesis using DTT","genericName":"Culture of removed prosthesis using DTT","companyName":"Hospices Civils de Lyon","companyId":"hospices-civils-de-lyon","modality":"Biologic","firstApprovalDate":"","aiSummary":"This is a diagnostic/microbiological procedure that cultures removed prosthetic material treated with dithiothreitol (DTT) to identify bacterial biofilms and infections. Used for Diagnosis of prosthetic joint infection (PJI), Identification of biofilm-associated infections on removed prosthetic devices.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}