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Daily dose of cholecalciferol per os
Daily dose of cholecalciferol per os is a Vitamin D supplement Small molecule drug developed by Hospices Civils de Lyon. It is currently in Phase 3 development for Vitamin D deficiency, Osteoporosis prevention or treatment, Immune function support.
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function. Used for Vitamin D deficiency, Osteoporosis prevention or treatment, Immune function support.
At a glance
| Generic name | Daily dose of cholecalciferol per os |
|---|---|
| Sponsor | Hospices Civils de Lyon |
| Drug class | Vitamin D supplement |
| Target | Vitamin D receptor (VDR) |
| Modality | Small molecule |
| Therapeutic area | Bone health, Immunology, Endocrinology |
| Phase | Phase 3 |
Mechanism of action
Cholecalciferol is a fat-soluble vitamin that undergoes hydroxylation in the liver and kidneys to form the active hormone calcitriol (1,25-dihydroxyvitamin D3). This active metabolite binds to the vitamin D receptor (VDR) in target tissues, promoting intestinal calcium and phosphate absorption, bone mineralization, and immune cell differentiation and function. Vitamin D deficiency is associated with impaired calcium homeostasis, bone disease, and dysregulated immunity.
Approved indications
- Vitamin D deficiency
- Osteoporosis prevention or treatment
- Immune function support
Common side effects
- Hypercalcemia
- Hypercalciuria
- Nausea
- Constipation
- Headache
Key clinical trials
- Impact of Vitamin D Supplementation on the Rate of Pathologic Complete Response in Vitamin D Deficient Patients (PHASE2)
- Effects of Cofrogliptin on Beta-Cell Function in LADA Patients (NA)
- Effect of Vitamin D and Folic Acid on Mild Cognitive Impairment (NA)
- Statin and Vitamin D Treatment in Patients With Thyroid Eye Disease (NA)
- Vitamin D Versus Desmopressin Versus Combination Therapy in Children With Primary Monosymptomatic Nocturnal Enuresis and Vitamin D Deficiency (NA)
- Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients (PHASE2)
- Low vs. Moderate to High Dose Vitamin D for Prevention of COVID-19 (NA)
- Vitamin D Sulfates in Breastmilk (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Daily dose of cholecalciferol per os CI brief — competitive landscape report
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- Hospices Civils de Lyon portfolio CI
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Related
- Drug class: All Vitamin D supplement drugs
- Target: All drugs targeting Vitamin D receptor (VDR)
- Manufacturer: Hospices Civils de Lyon — full pipeline
- Therapeutic area: All drugs in Bone health, Immunology, Endocrinology
- Indication: Drugs for Vitamin D deficiency
- Indication: Drugs for Osteoporosis prevention or treatment
- Indication: Drugs for Immune function support
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