Last reviewed · How we verify
Midazolam oral intake
Midazolam oral intake is a Benzodiazepine Small molecule drug developed by Hospices Civils de Lyon. It is currently in Phase 3 development for Procedural sedation and anxiolysis, Preoperative anxiety management, Acute anxiety disorders.
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation and anxiolysis.
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation and anxiolysis. Used for Procedural sedation and anxiolysis, Preoperative anxiety management, Acute anxiety disorders.
At a glance
| Generic name | Midazolam oral intake |
|---|---|
| Sponsor | Hospices Civils de Lyon |
| Drug class | Benzodiazepine |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Psychiatry/Neurology |
| Phase | Phase 3 |
Mechanism of action
Midazolam binds to GABA-A receptors and potentiates the effect of the inhibitory neurotransmitter GABA, leading to increased chloride ion influx and neuronal hyperpolarization. This results in depression of central nervous system activity, producing sedative, anxiolytic, anticonvulsant, and muscle relaxant effects. The oral formulation provides systemic absorption for procedural sedation and anxiety management.
Approved indications
- Procedural sedation and anxiolysis
- Preoperative anxiety management
- Acute anxiety disorders
Common side effects
- Drowsiness/sedation
- Dizziness
- Headache
- Respiratory depression
- Paradoxical agitation
Key clinical trials
- Reduction of Preoperative Anxiety in Children: Electronic Tab vs Midazolam (PHASE3)
- This Study Tests How Healthy Men Tolerate Different Doses of BI 730357 and How the Metabolism of Midazolam is Affected by BI 730357 (PHASE1)
- Acceptability of Various Available Midazolam Formulations (Syrup, Rectal Suppository, Oro-dispersible Minitablet) in Clinical Practice
- Human Genomic Population Structure and Phenotype-genotype Variation in ADME Genes in Four Populations (NA)
- Evaluation of the Potential Pharmacokinetic Interactions Between Probe Drugs in the Geneva Phenotyping Cocktail (PHASE1)
- Clinical Study to Assess Efficacy and Safety of Amiodarone in Treating Patients With Ebola. Virus Disease (EVD) in Sierra Leone. EASE (EMERGENCY Amiodarone Study Against Ebola) (PHASE2, PHASE3)
- Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. (PHASE2)
- Cocktail Approach for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spot (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Midazolam oral intake CI brief — competitive landscape report
- Midazolam oral intake updates RSS · CI watch RSS
- Hospices Civils de Lyon portfolio CI
Frequently asked questions about Midazolam oral intake
What is Midazolam oral intake?
How does Midazolam oral intake work?
What is Midazolam oral intake used for?
Who makes Midazolam oral intake?
What drug class is Midazolam oral intake in?
What development phase is Midazolam oral intake in?
What are the side effects of Midazolam oral intake?
What does Midazolam oral intake target?
Related
- Drug class: All Benzodiazepine drugs
- Target: All drugs targeting GABA-A receptor
- Manufacturer: Hospices Civils de Lyon — full pipeline
- Therapeutic area: All drugs in Psychiatry/Neurology
- Indication: Drugs for Procedural sedation and anxiolysis
- Indication: Drugs for Preoperative anxiety management
- Indication: Drugs for Acute anxiety disorders
- Compare: Midazolam oral intake vs similar drugs
- Pricing: Midazolam oral intake cost, discount & access