{"id":"midazolam-oral-intake","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness/sedation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Paradoxical agitation"}]},"_chembl":{"chemblId":"CHEMBL655","moleculeType":"Small molecule","molecularWeight":"325.77"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Midazolam binds to GABA-A receptors and potentiates the effect of the inhibitory neurotransmitter GABA, leading to increased chloride ion influx and neuronal hyperpolarization. This results in depression of central nervous system activity, producing sedative, anxiolytic, anticonvulsant, and muscle relaxant effects. The oral formulation provides systemic absorption for procedural sedation and anxiety management.","oneSentence":"Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation and anxiolysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:21:21.293Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Procedural sedation and anxiolysis"},{"name":"Preoperative anxiety management"},{"name":"Acute anxiety disorders"}]},"trialDetails":[{"nctId":"NCT02192710","phase":"PHASE3","title":"Reduction of Preoperative Anxiety in Children: Electronic Tab vs Midazolam","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2013-05","conditions":"Paediatric Outpatient Surgery","enrollment":118},{"nctId":"NCT03279978","phase":"PHASE1","title":"This Study Tests How Healthy Men Tolerate Different Doses of BI 730357 and How the Metabolism of Midazolam is Affected by BI 730357","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2018-01-09","conditions":"Healthy, Psoriasis","enrollment":83},{"nctId":"NCT05894057","phase":"","title":"Acceptability of Various Available Midazolam Formulations (Syrup, Rectal Suppository, Oro-dispersible Minitablet) in Clinical Practice","status":"UNKNOWN","sponsor":"University Children's Hospital Basel","startDate":"2023-06-06","conditions":"Medication Palatability","enrollment":100},{"nctId":"NCT02789527","phase":"NA","title":"Human Genomic Population Structure and Phenotype-genotype Variation in ADME Genes in Four Populations","status":"COMPLETED","sponsor":"Estella S. Poloni","startDate":"2015-11","conditions":"Healthy","enrollment":367},{"nctId":"NCT02391688","phase":"PHASE1","title":"Evaluation of the Potential Pharmacokinetic Interactions Between Probe Drugs in the Geneva Phenotyping Cocktail","status":"COMPLETED","sponsor":"Jules Desmeules","startDate":"2014-11","conditions":"Drug Interaction","enrollment":30},{"nctId":"NCT02307591","phase":"PHASE2, PHASE3","title":"Clinical Study to Assess Efficacy and Safety of Amiodarone in Treating Patients With Ebola. Virus Disease (EVD) in Sierra Leone. EASE (EMERGENCY Amiodarone Study Against Ebola)","status":"WITHDRAWN","sponsor":"Emergency NGO Onlus","startDate":"2014-12","conditions":"Ebola Virus Disease","enrollment":""},{"nctId":"NCT02104271","phase":"PHASE2","title":"Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial.","status":"COMPLETED","sponsor":"Barretos Cancer Hospital","startDate":"2013-01","conditions":"Radiation Injuries, Telangiectasis, Rectal Bleeding","enrollment":41},{"nctId":"NCT01731067","phase":"PHASE1","title":"Cocktail Approach for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spot","status":"COMPLETED","sponsor":"Jules Desmeules","startDate":"2012-11","conditions":"Healthy Volunteers","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":27,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Midazolam oral intake","genericName":"Midazolam oral intake","companyName":"Hospices Civils de Lyon","companyId":"hospices-civils-de-lyon","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation and anxiolysis. Used for Procedural sedation and anxiolysis, Preoperative anxiety management, Acute anxiety disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}