Benzodiazepine
This page covers all Benzodiazepine drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting GABA-A receptor, GABA-A receptor (allosteric modulator), GABA A receptor alpha-5/beta-2/gamma-2.
Targets
GABA-A receptor · GABA-A receptor (allosteric modulator) · GABA A receptor alpha-5/beta-2/gamma-2 · GABA-A receptor alpha-1/beta-2/gamma-2 · Histamine H1 receptor · GABA_A receptor · GABAA receptor
Marketed (36)
- Lorazepam and fMRI · University of Michigan · Neurology; Psychiatry
Lorazepam is a benzodiazepine that enhances GABAergic inhibitory neurotransmission in the central nervous system, and fMRI is a neuroimaging technique used to visualize brain activity changes in response to the drug. - Midazolam Mylan · Universitaire Ziekenhuizen KU Leuven · Central Nervous System / Anesthesia
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation, anxiolysis, and muscle relaxation. - midazolam in children premedication · Azienda Ospedaliera Universitaria Policlinico "G. Martino" · Anesthesia/Sedation
Midazolam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system to produce sedation and anxiolysis. - Ativan® · University of South Florida · Psychiatry/Neurology
Ativan (lorazepam) enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, reducing neuronal excitability. - Remimazolam based total intravenous anesthesia · The First Affiliated Hospital of Anhui Medical University · Anesthesia
Remimazolam is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors, producing sedation and anesthesia. - Oral estazolam medication · The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine · Neurology / Sleep Medicine
Estazolam is a benzodiazepine that enhances the inhibitory effects of GABA at the GABA-A receptor, promoting sedation and sleep. - Buccal midazolam · Hamad Medical Corporation · Neurology, Anesthesia
Buccal midazolam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system to produce sedation and anxiolysis. - Diazepam 2Mg encapsulated Tab · The University of Hong Kong · Metabolic
- Clinical-judged midazolam administration · Chang Gung Memorial Hospital · Anesthesia/Sedation
Midazolam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system to produce sedation, anxiolysis, and amnesia. - Versed · Takeda Pharmaceutical Company Limited · Neuroscience
- I/N Midazolam · Shaheed Zulfiqar Ali Bhutto Medical University · Anesthesia, Sedation, Anxiety
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at the GABA-A receptor, producing sedation, anxiolysis, and muscle relaxation. - Midazolam (active placebo) · Taipei Veterans General Hospital, Taiwan · Neurology; Anesthesia; Psychiatry
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation and anxiolysis. - Lorazepam Mylan · Universitaire Ziekenhuizen KU Leuven · Psychiatry/Neurology
Lorazepam enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, reducing neuronal excitability. - Intranasal Midazolam · Hamad Medical Corporation · Neurology; Psychiatry
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation and anxiolysis. - Midazolam sedation · University of Liege · Anesthesia/Sedation
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation and anxiolysis. - Midazolam - active comparator · Assaf-Harofeh Medical Center · Neurology, Anesthesia, Psychiatry
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at the GABA-A receptor, depressing central nervous system activity. - Dalmane · Neuroscience
- Chlordiazepoxide Hydrochloride · Bausch Health · Neuroscience
- lorazepam (Ativan) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) · Psychiatry, Neurology
Lorazepam enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, reducing neuronal excitability. - (alprax) alprazolam · B.P. Koirala Institute of Health Sciences · Psychiatry/Neurology
Alprazolam enhances the inhibitory effects of GABA at the GABA-A receptor in the central nervous system, reducing neuronal excitability and producing anxiolytic and sedative effects. - Intramuscular midazolam · Hamad Medical Corporation · Psychiatry/Neurology
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation, anxiolysis, and muscle relaxation. - Midazolam load · University of Pennsylvania · Anesthesia, Sedation, Anxiety
Midazolam is a benzodiazepine that enhances inhibitory GABA neurotransmission in the central nervous system to produce sedation, anxiolysis, and amnesia. - midazolam intravenous administration · University Hospital, Lille · Anesthesia/Sedation
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation, anxiolysis, and amnesia. - nasal diazepam · University of Cincinnati · Neurology; Psychiatry
Nasal diazepam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system when administered intranasally. - Oral alprazolam · Isfahan University of Medical Sciences · Psychiatry/Neurology
Alprazolam enhances the inhibitory effects of GABA at the GABA-A receptor, reducing neuronal excitability and producing anxiolytic and sedative effects. - Continuous Infusion Remimazolam · Second Affiliated Hospital of Wenzhou Medical University · Anesthesia/Sedation
Remimazolam is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors, producing sedation and anxiolysis. - Diazepam Tablets · Queen Sirikit National Institute of Child Health · Neurology, Psychiatry
Diazepam enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, reducing neuronal excitability. - Diazepam Injectable Solution · Centro Medico Nacional La Raza, IMSS · Neurology, Psychiatry, Critical Care
Diazepam enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, reducing neuronal excitability. - Midazolam (sedative) · Technische Universität Dresden · Neurology / Anesthesia
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation and anxiolysis. - Rematazolam Besylate · Second Affiliated Hospital of Nanchang University · Neurology / Anesthesia
Rematazolam besylate is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors in the central nervous system. - remimazolam group · Gangnam Severance Hospital · Anesthesia/Sedation
Remimazolam is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors, producing sedation and anxiolysis. - Remimazolam Tosilate for Injection · Jiangsu HengRui Medicine Co., Ltd. · Anesthesia/Sedation
Remimazolam is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors, producing sedation and anxiolysis. - Tranxene · Ajenat Pharms · Neuroscience
- Lorazepam (drug) · University of Manitoba · Psychiatry, Neurology
Lorazepam enhances the inhibitory effects of GABA at the GABA-A receptor, reducing neuronal excitability and producing sedative, anxiolytic, and anticonvulsant effects. - Alprazolam (Xanax) · University of California, San Diego · Psychiatry/Neurology
Alprazolam enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, reducing neuronal excitability and producing anxiolytic and sedative effects. - Valtoco Nasal Product · University Hospitals Cleveland Medical Center · Neurology
Valtoco is a nasal spray formulation of diazepam that rapidly delivers the benzodiazepine to the systemic circulation to provide fast-acting seizure relief.
Phase 3 pipeline (13)
- Sedation with midazolam · Consorci Sanitari de l'Anoia · Anesthesia/Sedation
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at the GABA-A receptor, depressing central nervous system activity to produce sedation. - Midazolam HCI · Eisai Inc. · Neurology/Anesthesia
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation, anxiolysis, and muscle relaxation. - Midazolam oral intake · Hospices Civils de Lyon · Psychiatry/Neurology
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation and anxiolysis. - Auris-Sedina · Laboratorios Osorio de Moraes Ltda. · Neurology
Auris-Sedina is a sedative-hypnotic agent used to treat insomnia. - Extended-release lorazepam · Edgemont Pharmaceuticals, LLC · Psychiatry / Neurology
Extended-release lorazepam is a benzodiazepine that enhances the inhibitory neurotransmitter GABA at the GABA-A receptor, producing anxiolytic, sedative, and anticonvulsant effects. - Clobazam Medium Dose · Lundbeck LLC · Neurology
Clobazam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system to reduce seizure activity. - Anesthesia induction with remimazolam · Daegu Catholic University Medical Center · Anesthesiology
Remimazolam is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors, producing rapid sedation and anesthesia induction. - The midazolam group · Kasr El Aini Hospital · Anesthesia, Sedation, Anxiety
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at the GABA-A receptor, producing sedation, anxiolysis, and muscle relaxation. - DZP · UCB Biopharma SRL · Neurology, Psychiatry
DZP is a benzodiazepine that enhances GABAergic neurotransmission by potentiating the effect of GABA at GABA-A receptors in the central nervous system. - Clobazam High Dose · Lundbeck LLC · Neurology
Clobazam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system to reduce seizure activity. - Midazolam Nasal Spray · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Neurology / Anesthesia
Midazolam is a benzodiazepine that enhances inhibitory GABA neurotransmission in the central nervous system to produce sedation and anxiolysis. - Alprazolam orally disintegrating tablets · UCB Pharma · Psychiatry/Neurology
Alprazolam is a benzodiazepine that enhances the inhibitory effects of GABA at the GABA-A receptor, reducing neuronal excitability and producing anxiolytic and sedative effects. - Staccato alprazolam · UCB Biopharma SRL · Psychiatry / Neurology
Staccato alprazolam is a rapidly-absorbed inhaled formulation of alprazolam that binds to GABA-A receptors in the central nervous system to enhance inhibitory neurotransmission.
Phase 2 pipeline (2)
- D. Midazolam · Paion UK Ltd. · Oncology
GABA_A receptor agonist - C=Inhaled Alprazolam 1 m · Alexza Pharmaceuticals, Inc. · Neurology
Alprazolam acts as a positive allosteric modulator of the GABAA receptor, enhancing the inhibitory effects of GABA in the central nervous system.