Histamine H1 receptor — Drug Target
All drugs that target Histamine H1 receptor — marketed and clinical-stage. Includes 44 drug classes acting on this target.
Drug classes
First-generation H1 receptor antagonist (antihistamine) · Benzodiazepine · Antihistamine · Muscle Relaxant · buclizine · Adrenergic Receptor Agonist · Histamine-1 Receptor Antagonist · triprolidine · brompheniramine · azatadine · dexchlorpheniramine · bromazine
Marketed (51)
- Diphenhydramine HCL · National Cancer Institute (NCI) · First-generation H1 receptor antagonist (antihistamine) · Allergy/Immunology
Diphenhydramine blocks histamine H1 receptors, preventing histamine-mediated allergic and inflammatory responses. - Chlordiazepoxide Hydrochloride · Bausch Health · Benzodiazepine · Neuroscience
- CHLORPHENIRAMINE · Antihistamine · Respiratory
- Amrix · Muscle Relaxant · Neuroscience
- Buclifen · buclizine · Other
- Elestat · AbbVie · Adrenergic Receptor Agonist · Other
Elestat works by binding to the histamine H1 receptor, blocking the action of histamine and reducing allergic symptoms. - Tussionex Pennkinetic · Bayer · Histamine-1 Receptor Antagonist · Neuroscience
- Actidil · Novartis · triprolidine · Infectious Disease
- Dimetane-Dx · brompheniramine · Infectious Disease
- Azatidine · azatadine · Infectious Disease
- Dexchlorpheniramine Maleate · dexchlorpheniramine · Immunology
- Semprex-D · Auxilium Pharms Inc · Histamine-1 Receptor Antagonist · Infectious Disease
- Bromanautine · Allergan/AbbVie · bromazine · Immunology
- Mizollen · Sanofi · mizolastine · Other
- Phenazoline · Novartis · antazoline · Immunology
- Norflex · Muscle Relaxant · Neuroscience
- Zaditor · Histamine-1 Receptor Inhibitor · Ophthalmology
- Cyproheptadine Hydrochloride · cyproheptadine · Dermatology
- Diazolinum · mebhydrolin · Immunology
- Marezine · GSK · cyclizine · Immunology
- (+/-)-Mianserin · mianserin · Neuroscience
- Endep · AstraZeneca · Tricyclic Antidepressant · Neuroscience
- H1 Antihistaminics · Erasmus Medical Center · H1 receptor antagonist · Allergy/Immunology
H1 antihistaminics block histamine H1 receptors on cell surfaces, preventing histamine-mediated allergic and inflammatory responses. - Temaril · trimeprazine · Dermatology
- Claritin® · Sanofi · Second-generation H1-receptor antagonist (non-sedating antihistamine) · Immunology / Allergy
Claritin blocks histamine H1 receptors on cells, preventing histamine-mediated allergic responses. - Unisom · Chattem · Antihistamine · Infectious Disease
- Tussionex Pennkinetic · Bayer · Histamine-1 Receptor Antagonist · Immunology
- Levocetirizine plus Hydroxyzine · Association Asthma, Bulgaria · H1-receptor antagonist combination · Allergy/Immunology
This combination blocks histamine H1 receptors to reduce allergic symptoms and itching. - Bepreve · North Texas Institute for Clinical Trials · Other
- Doxylamin · St. Petersburg Bekhterev Research Psychoneurological Institute · Infectious Disease
- Karbinal Er · Mcneil · Histamine-1 Receptor Antagonist · Infectious Disease
Karbinal Er works by blocking the histamine H1 receptor, a key player in the body's allergic response. - Bastel · ebastine · Immunology
- Lastacaft · AbbVie · Histamine-1 Receptor Antagonist [EPC] · Other
Lastacaft blocks histamine at the H1 receptor to reduce allergic symptoms. - Zonalon · Tricyclic Antidepressant · Immunology
Zonalon works by blocking histamine H1 receptors in the brain, which helps to reduce anxiety and itching, and improve mood. - Surmontil · Teva Womens · Tricyclic Antidepressant · Neuroscience
- Dimenhydrinate · Alra · dimenhydrinate · Pain
- Astelin · Bayer · Histamine-1 Receptor Antagonist · Metabolic
- Dexchlorpheniramine or Diphenhydramine · Sanofi · H1 receptor antagonist (first-generation antihistamine) · Allergy/Immunology
Blocks histamine H1 receptors to reduce allergic and inflammatory responses. - Dothiepin · All India Institute of Medical Sciences, Bhubaneswar · Tricyclic Antidepressants · Neuroscience
- Rupax · Teikoku Seiyaku · rupatadine · Immunology
Phase 3 pipeline (6)
- Chlorpheniramine maleate syrup · Organon and Co · H1 receptor antagonist (first-generation antihistamine) · Allergy/Immunology
Chlorpheniramine maleate blocks histamine H1 receptors to reduce allergic symptoms and itching. - Desloratadine (Clarinex) · Organon and Co · Non-sedating H1-receptor antagonist · Immunology / Allergy
Desloratadine is a selective histamine H1-receptor antagonist that blocks histamine-mediated allergic responses without significant central nervous system penetration. - Clemizole HCl · Epygenix · H1-receptor antagonist (antihistamine) · Immunology / Allergy / Inflammation
Clemizole HCl is a histamine H1-receptor antagonist that blocks histamine-mediated immune and inflammatory responses. - diphenhydramine ampule · Ministry Of Health / Nineveh Health Directorate · Antihistamine · Allergy
Diphenhydramine acts as an antihistamine by blocking the action of histamine in the body. - Placebo + anti-H1 · University Hospital, Tours · H1-receptor antagonist (antihistamine) · Immunology / Allergy
Placebo combined with an anti-H1 antihistamine blocks histamine H1 receptors to reduce allergic and inflammatory responses. - Bilastin · Charite University, Berlin, Germany · Other
Phase 2 pipeline (8)
- Alfadryl · moxastine · Neuroscience
Alfadryl works by binding to the histamine H1 receptor, blocking the action of histamine and reducing symptoms of allergic reactions. - Cinarizine · cinnarizine · Neuroscience
Cinarizine works by blocking histamine receptors in the brain, which helps to reduce symptoms of motion sickness and vertigo. - Alcaftadine Ophthalmic Solution 0.25% · Allergan · Antihistamine · Ophthalmology
Antihistamine - Acepromethazine · Neuroscience
Acepromethazine works by blocking histamine receptors in the brain to promote sleep. - Bamipin · bamipine · Immunology
Bamipine blocks histamine at the H1 receptor to treat urticaria. - Levocetirizine tablets · UCB Pharma · Antihistamine · Respiratory
Selective histamine H1 receptor antagonist - Clemastine IV · Erasmus Medical Center · Antihistamine · Allergy
Histamine H1 receptor antagonist - Bepotastine besilate-fluticasone propionate · Bausch & Lomb Incorporated · Antihistamine and corticosteroid combination · Ophthalmology
Histamine H1 receptor antagonist and corticosteroid combination