What is Norflex used for?

Norflex is indicated for Acute painful musculoskeletal conditions.

Norflex is developed by Pai Holdings Pharm.

What development phase is Norflex in?

Norflex is FDA-approved (marketed).

What are the side effects of Norflex?

Common side effects include Pneumonia viral, Soft tissue disorder, Herpes zoster, Oral pain, Fibromyalgia, Liver function test abnormal.

What is the generic name of Norflex?

ORPHENADRINE is the generic (nonproprietary) name of Norflex.

Last reviewed 2026-04-20 · How we verify

Norflex (ORPHENADRINE)

Pai Holdings Pharm · FDA-approved approved Small molecule Quality 48/100

At a glance

Generic name	ORPHENADRINE
Sponsor	Pai Holdings Pharm
Drug class	Muscle Relaxant
Target	Histamine H1 receptor
Modality	Small molecule
Therapeutic area	Neuroscience
Phase	FDA-approved
First approval	1957

Approved indications

Acute painful musculoskeletal conditions

Common side effects

Pneumonia viral
Soft tissue disorder
Herpes zoster
Oral pain
Fibromyalgia
Liver function test abnormal
Blood cholesterol increased
Leukopenia
Arthritis
Peripheral swelling
Synovitis
Tenderness

Drug interactions

sodium oxybate

Key clinical trials

Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism Pain (PHASE4)
Clinical Response of Nuberol Forte in Chronic Neck Pain in Routine Rehabilitation Centers
Efficiency and Safety a Fixed Combination of Orphenadrine and Diclofenac for Postoperative Analgesia (NA)
Neodolpasse® Infusion Solution Versus Diclofenac 75 mg Infusion in the Treatment of Postoperative Pain After Elective Knee Surgery (PHASE4)
Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery (PHASE4)
Orphenadrine Versus Baclofen in Treatment of Muscle Cramps in Cirrhotic Patients (NA)
Safety & Efficacy of Nuberol Forte® in Pain Management
Comparison of Post-Operative Analgesia After Percutaneous Nephrolithotomy. (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
FDA label	Mechanism, indications, dosing, boxed warnings, drug interactions
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Norflex CI brief — competitive landscape report
Norflex updates RSS · CI watch RSS