Last reviewed · How we verify
Tussionex Pennkinetic (chlorphenamine)
Tussionex Pennkinetic, also known as chlorphenamine, is a small molecule histamine-1 receptor antagonist developed by BAYER HEALTHCARE LLC. It was first approved by the FDA in 1950 for various allergic conditions, including allergic conjunctivitis, rhinitis, and skin itching. As a histamine-1 receptor antagonist, Tussionex Pennkinetic works by blocking the action of histamine at its receptor site, thereby reducing symptoms of allergic reactions. The commercial status of Tussionex Pennkinetic is owned by BAYER HEALTHCARE LLC, and its key safety considerations include its potential for drowsiness and interactions with other medications. Overall, Tussionex Pennkinetic is a well-established medication for the treatment of allergic conditions.
At a glance
| Generic name | chlorphenamine |
|---|---|
| Sponsor | Bayer |
| Drug class | Histamine-1 Receptor Antagonist |
| Target | Histamine H1 receptor |
| Therapeutic area | Immunology |
| Phase | FDA-approved |
| First approval | 1950 |
Approved indications
- Allergic conjunctivitis
- Allergic rhinitis
- Common cold
- Dermatographic urticaria
- Influenza-like symptoms
- Itching of skin
- Nasal congestion
- Nasal discharge
- Seasonal allergic rhinitis
- Sneezing
- Urticaria
- Vasomotor rhinitis
Common side effects
- Nausea
- Vomiting
- Sedation
- Drowsiness
- Mental clouding
- Lethargy
- Dizziness
- Mood changes
- Constipation
- Dryness of the pharynx
- Anxiety
- Fear
Serious adverse events
- Respiratory depression
- Fatal respiratory depression
- Death
- Ureteral spasm
- Spasm of vesical sphincters
Key clinical trials
- Study of the Interest of Pursuing or Not the Chemotherapy for Patients With Metastatic Esophageal Cancer (PHASE2)
- Obinutuzumab in Adult Rituximab-Dependent Nephrotic Syndrome (PHASE2)
- A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Negative, Chronic Hepatitis B Virus (HBV) Infection (PHASE2)
- Extension Study of the Safety and Efficacy of Multi-dose Intravenous ARC-520 in Patients With Chronic Hepatitis B (HBV) Infection (PHASE2)
- Study of ARC-520 With or Without Other Drugs Used in the Treatment of Chronic Chronic Hepatitis B Virus (HBV) (PHASE2)
- A Multicenter Study to Determine the Depth and Duration of Hepatitis B Surface Antigen (HBsAg) Reduction After Single or Multiple Doses of ARC-520, in Combination With Entecavir in Patients With Chronic Hepatitis B Virus (HBV) Infection (PHASE2)
- A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Positive, Chronic Hepatitis B Virus Infection (PHASE2)
- A Study of ARC-521 Injection in Normal Adult Volunteers and Patients With Chronic Hepatitis B (CHB) (PHASE1)
Patents
| Patent | Expiry | Type |
|---|---|---|
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
| FDA Orange Book | Patents + exclusivity |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tussionex Pennkinetic CI brief — competitive landscape report
- Tussionex Pennkinetic updates RSS · CI watch RSS
- Bayer portfolio CI