Bayer AG (BAYRY)

Quick facts

Marketed products

• Nubeqa · Oncology · revenue 1600
  Darolutamide inhibits androgen receptor activity, reducing prostate cancer cell growth and tumor size.
• Aspirin · revenue 1000.0
  Irreversibly inhibits cyclooxygenase-1 and -2 (COX-1/COX-2), blocking prostaglandin and thromboxane synthesis to reduce pain, inflammation, fever, and platelet aggregation.
• Kerendia · Metabolic · revenue 600
  Kerendia works by blocking the mineralocorticoid receptor, a protein that regulates sodium and potassium levels in the body.
• Xofigo · Oncology · revenue 400
  Xofigo works by emitting alpha particles that selectively target and kill cancer cells in the prostate.
• Stivarga · Oncology · revenue 400
  Stivarga blocks the activity of enzymes involved in tumor growth and angiogenesis.
• Nexavar · Oncology · revenue 200
• Precose · Metabolic
• Acarbose (Glucobay, BAYG5421) · Diabetes
  Acarbose inhibits intestinal alpha-glucosidase enzymes to slow the digestion and absorption of carbohydrates, reducing postprandial blood glucose spikes.
• Adalat (Nifedipine, BAYA1040) · Cardiovascular
  Nifedipine blocks calcium influx into vascular smooth muscle and cardiac cells, causing vasodilation and reduced blood pressure.
• Advil · Other
• Alka Seltzer Extra Strength · Gastroenterology; Pain Management
  Alka-Seltzer Extra Strength combines aspirin, citric acid, and sodium bicarbonate to neutralize stomach acid and provide analgesic and anti-inflammatory relief.
• Domeboro · Infectious Disease
• Amlodipine (Norvasc) · Cardiovascular
  Amlodipine blocks calcium channels in vascular smooth muscle and cardiac tissue, causing vasodilation and reduced blood pressure.
• Trasylol · Hematology
• Shade Uvaguard · Dermatology
  Shade Uvaguard works by absorbing and scattering UV radiation to prevent skin damage.
• Astelin · Metabolic
• AZLOCILLIN · Metabolic
• Betaferon/Betaseron · Immunology/Neurology
  Betaferon is interferon beta-1b, which activates immune cells and reduces inflammatory responses in the central nervous system to slow disease progression.
• Mentax · Infectious Disease
• Femstat 3 · Infectious Disease
• Baycol · Metabolic
• Tussionex Pennkinetic · Immunology
• Tussionex Pennkinetic · Neuroscience
• Cipro · Neuroscience
• Lotrimin · Infectious Disease
• COMPLERA · Other
• Conventional medical treatment
  Conventional medical treatment refers to standard, evidence-based therapeutic approaches using established drugs and interventions rather than experimental or novel therapies.
• Aliqopa · Oncology
• Coracten · Other
• Dabigatran etexilate (Pradaxa) · Cardiovascular
  Dabigatran etexilate is a prodrug that converts to dabigatran, a direct thrombin inhibitor that blocks the final step of the coagulation cascade.
• Dtic-Dome · Oncology
• Dexpanthenol (BAY81-2996) · Dermatology / Wound Care
  Dexpanthenol is converted to pantothenic acid (vitamin B5), which serves as a precursor for coenzyme A, essential for cellular metabolism and tissue repair.
• Diagnostic procedures · Diagnostics
  Diagnostic procedures are clinical or imaging techniques used to identify, visualize, or confirm the presence of disease or medical conditions.
• Diane · Other
• Diovan · Cardiovascular
• Diovan (Valsartan) · Cardiovascular
  Valsartan blocks angiotensin II receptors on blood vessels and the heart, causing vasodilation and reducing blood pressure.
• EE20/DRSP (YAZ, BAY86-5300) · Contraception / Gynecology
  EE20/DRSP is an oral contraceptive combining ethinyl estradiol and drospirenone to prevent ovulation and thicken cervical mucus.
• Phosphestrol · Other
• Gadavist · Hematology
  Gadavist works by binding to gadolinium ions, which then accumulate in body tissues and enhance MRI signal.
• Gadoterate (Dotarem/Clariscan) · Diagnostic Imaging
  Gadoterate is a gadolinium-based contrast agent that accumulates in tissues and enhances MRI signal to improve visualization of anatomical structures and lesions.

Phase 3 pipeline

• Amoxicilline/clavulanic · Infectious Disease
  Amoxicillin/clavulanic acid is a beta-lactam antibiotic combination that kills bacteria by inhibiting cell wall synthesis, with clavulanic acid protecting amoxicillin from degradation by bacterial beta-lactamases.
• BAY 59-7939 · Cardiovascular
  BAY 59-7939 is a direct Factor Xa inhibitor that blocks the coagulation cascade to prevent thrombus formation.
• BAY2927088 · Oncology
  BAY2927088 is a fibroblast growth factor receptor (FGFR) inhibitor that blocks FGFR signaling to inhibit tumor cell proliferation and survival.
• BAY3723113 · Oncology
  BAY3723113 is a selective inhibitor of fibroblast growth factor receptor 4 (FGFR4) that blocks aberrant FGF/FGFR signaling in hepatocellular carcinoma and other cancers.
• BAY86-4980 · Oncology
  BAY86-4980 is a selective inhibitor of phosphoinositide 3-kinase (PI3K) that blocks PI3K signaling to suppress tumor cell proliferation and survival.
• BAY86-5016, SH P00331F · Cardiovascular
  BAY86-5016 is a Factor IIa (thrombin) inhibitor that directly blocks the active site of thrombin to prevent blood clot formation.
• BAY86-5300 · Oncology
  BAY86-5300 is a selective inhibitor of phosphoinositide 3-kinase (PI3K) that blocks PI3K signaling to suppress tumor cell proliferation and survival.
• BAY94-9027 · Hematology
  BAY94-9027 is a long-acting factor VIII replacement therapy that extends the half-life of clotting factor VIII through PEGylation, reducing dosing frequency in hemophilia A patients.
• Best standard of care (BSoC)
  Best standard of care (BSoC) is a comparator arm designation used in clinical trials, not a drug with a specific mechanism of action.
• Bifonazole cream 1% · Dermatology
  Bifonazole inhibits fungal cell membrane synthesis by disrupting ergosterol production through inhibition of lanosterol 14α-demethylase.
• Butenafine HCl 1% (BAY1896425) · Dermatology / Infectious Disease
  Butenafine HCl is an allylamine antifungal that disrupts fungal cell membrane integrity by inhibiting squalene epoxidase, leading to ergosterol depletion.
• Ceftriaxone; Azithromycin; Amoxicilline/clavulanate; Clarithromycin · Infectious Disease
  This is a combination of four beta-lactam and macrolide antibiotics that work by inhibiting bacterial cell wall synthesis and protein synthesis to kill or inhibit growth of susceptible bacteria.
• Ciprofloxacin (BAYO9867) · Infectious Disease
  Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
• Ciprofloxacin DPI (BAYQ3939) · Infectious Disease
  Ciprofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
• Ciprofloxacin single dose · Infectious Disease
  Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
• Ciprofloxacin triple dose · Infectious Disease
  Ciprofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
• Clotrimazole, vaginal ovule · Infectious Disease
  Clotrimazole disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis, leading to cell death.
• Copanlisib (BAY 80-6946) · Oncology
  Copanlisib is a pan-class I phosphatidylinositol 3-kinase (PI3K) inhibitor that blocks PI3K signaling to suppress tumor cell proliferation and survival.
• Drospirenone/Ethinylestradiol/Methyltetrahydrofolate · Contraception / Women's Health
  This combination oral contraceptive prevents pregnancy by suppressing ovulation through progestin and estrogen activity, while methyltetrahydrofolate supplementation reduces neural tube defect risk.
• Drug: YAZ flex (SH T00186D) · Contraception / Women's Health
  YAZ flex is an oral contraceptive that prevents ovulation through a combination of ethinyl estradiol and drospirenone, with a flexible dosing regimen.
• Elinzanetant (BAY3427080) · Women's Health / Endocrinology
  Elinzanetant is a neurokinin-3 (NK3) receptor antagonist that reduces vasomotor symptoms by blocking neurokinin signaling in the hypothalamus.
• Enoxaparin followed by VKA · Cardiovascular
  Enoxaparin is a low-molecular-weight heparin that inhibits blood clotting factors, followed by a vitamin K antagonist (VKA) to maintain long-term anticoagulation.
• Ertapenem intravenous · Infectious Disease
  Ertapenem is a broad-spectrum beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
• Estradiol (E2 0.3mg) · Endocrinology / Women's Health
  Estradiol is a naturally occurring estrogen that binds to estrogen receptors (ERα and ERβ) to modulate hormone-dependent physiological processes.
• EV/DNG (Qlaira, BAY86-5027) · Contraception / Women's Health
  EV/DNG is an estradiol valerate and dienogest combination oral contraceptive that prevents ovulation through hormonal suppression.
• Finerenone (BAY94-8862) · Cardiovascular, Nephrology
  Finerenone is a non-steroidal mineralocorticoid receptor antagonist that blocks aldosterone signaling to reduce inflammation and fibrosis in the kidneys and cardiovascular system.
• Gadoquatrane (BAY1747846) · Diagnostic Imaging
  Gadoquatrane is a gadolinium-based contrast agent designed for magnetic resonance imaging (MRI) that provides enhanced visualization of blood vessels and tissues.
• Gadoteridol (ProHance) · Diagnostic Imaging
  Gadoteridol is a gadolinium-based contrast agent that enhances magnetic resonance imaging (MRI) by shortening the T1 relaxation time of water protons in tissues.
• Gynodian® Depot (BAY86-5032) · Endocrinology / Gynecology
  Gynodian Depot is a long-acting gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone to reduce estrogen levels.
• Laif® 900, BAY98-7108 · Psychiatry / Mental Health
  Laif 900 is a standardized St. John's Wort extract that modulates serotonin and other neurotransmitter systems to improve mood in depression.
• LCS12 · Cardiovascular
  LCS12 is a small molecule that inhibits the PCSK9 enzyme.
• LCS16 · Cardiovascular
  LCS16 is a small molecule that inhibits the PCSK9 enzyme.
• Levofloxacin + Ceftriaxone · Infectious Disease
  This combination uses a fluoroquinolone antibiotic to inhibit bacterial DNA gyrase and topoisomerase IV, while a third-generation cephalosporin inhibits bacterial cell wall synthesis, providing broad-spectrum coverage against gram-positive and gram-negative bacteria.
• Levonorgestrel (BAY98-7196) · Contraception
  Levonorgestrel is a synthetic progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions.
• LNG-IUS (BAY 86-5028) · Contraception / Gynecology
  LNG-IUS is a levonorgestrel-releasing intrauterine system that provides long-acting reversible contraception by releasing a synthetic progestin directly into the uterus.
• Magnevist (SH L 451A) · Diagnostic Imaging
  Magnevist is a gadolinium-based contrast agent that enhances magnetic resonance imaging (MRI) by shortening the T1 relaxation time of water protons in tissues.
• Minisiston (SH D00342A) · Contraception
  Minisiston is a progestin-only oral contraceptive that prevents pregnancy primarily through cervical mucus thickening and endometrial suppression.
• Molidustat (BAY85-3934) · Renal Anemia
  Molidustat activates hypoxia-inducible factor prolyl hydroxylase (HIF-PH) enzymes, leading to stabilization of HIF-α subunits and increased erythropoietin production.
• Naproxen sodium ER (BAYH6689) · Pain Management / Rheumatology
  Naproxen sodium ER is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.
• Nifurtimox (Lampit, BAYA2502) · Infectious Disease / Parasitology
  Nifurtimox is a nitrofuran compound that generates reactive oxygen species to kill parasites, particularly effective against Trypanosoma cruzi.

Phase 2 pipeline

• Anti-VEGF injections · Oncology
  Anti-VEGF injections work by binding to and inhibiting vascular endothelial growth factor (VEGF), a protein that promotes angiogenesis.
• anti-VEGF medication
• Antifibrinolytic treatment · Oncology
  Antifibrinolytic agents inhibit plasminogen activators and plasmin.
• Antithrombotic agents · Cardiovascular
  Antithrombotic agents work by inhibiting platelet aggregation and preventing blood clots.
• Any other OC · Women's Health
  Any other OC works by preventing ovulation.
• Assigned pulmonary hypertension medication · Cardiovascular
  This drug works by inhibiting the action of endothelin-1, a potent vasoconstrictor.
• BAY 1753011
• BAY 3401016
• Bay 59-8862 · Diabetes
  Bay 59-8862 is a selective and potent inhibitor of the sodium-glucose cotransporter 2 (SGLT2).
• BAY 77-1931 · Cardiovascular
  BAY 77-1931 is a direct thrombin inhibitor that blocks the active site of thrombin to prevent blood clot formation.
• BAY 94-8862 · Infectious disease
  BAY 94-8862 is a monoclonal antibody targeting SARS-CoV-2.
• BAY1002670
• BAY1142524
• BAY1193397
• BAY1213790
• BAY14-2222_Kogenate-FS FVIII · Hematology
  Factor VIII replacement therapy
• BAY2253651 · Oncology
  BAY2253651 is a small molecule that targets the CDK9 protein.
• BAY2433334
• BAY3018250 Dose 1
  BAY3018250 is a small molecule drug that targets the molecular target.
• BAY3283142
• BAY60-4552 plus Vardenafil · Cardiovascular
  BAY60-4552 activates soluble guanylate cyclase to increase cGMP levels, while vardenafil inhibits phosphodiesterase-5 to prevent cGMP degradation, synergistically enhancing vasodilation and improving erectile function.
• BAY73-4506
• BAY85-3934
• BAY85-8501 · Diabetes
  BAY85-8501 is a small molecule that targets the SGLT2 receptor.
• BAY86-4891
• BAY86-5046_Interferon-beta-1b · Neurology
  Interferon-beta-1b binds to the interferon-alpha/beta receptor, activating a signaling cascade that modulates immune responses.
• BAY86-5300_YAZ-Flex
• BAY86-6150 · Diabetes
  BAY86-6150 is a small molecule that inhibits the SGLT2 receptor.
• BAY94-8862
• BAY98-7443 · Diabetes
  BAY98-7443 is a small molecule that acts as a selective and potent inhibitor of the sodium-glucose cotransporter 2 (SGLT2).
• Betaferon, BAY86-5046 · Immunology
  Betaferon is an immunomodulatory drug that works by inhibiting the production of interferon-gamma, a cytokine involved in the immune response.
• Bifonazole spray once daily · Infectious Diseases
  Bifonazole is an antifungal agent that works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes.
• Bifonazole spray twice daily · Dermatology
  Bifonazole is an antifungal agent that works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes.
• Chronic hormonal treatment
• Conventional FVIII replacement therapies
• Darolutamide plus ADT treatment
• Data on other treatments
• Dehydroepiandrosterone, BAY86-5314 · Oncology, Endocrinology
  Dehydroepiandrosterone is a naturally occurring steroid hormone that has been investigated for its potential therapeutic effects.
• Dexpanthenol foam spray, new formulation · Dermatology
  Dexpanthenol, a form of vitamin B5, helps to soothe and protect the skin by promoting the healing of wounds and reducing inflammation.
• Dexpanthenol foam spray, old formulation

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Bayer AG portfolio CI brief
• Bayer AG pipeline updates RSS