Last reviewed · How we verify
Alka Seltzer Extra Strength
Alka-Seltzer Extra Strength combines aspirin, citric acid, and sodium bicarbonate to neutralize stomach acid and provide analgesic and anti-inflammatory relief.
Alka-Seltzer Extra Strength combines aspirin, citric acid, and sodium bicarbonate to neutralize stomach acid and provide analgesic and anti-inflammatory relief. Used for Heartburn and indigestion relief, Mild to moderate pain and fever, Acid reflux symptoms.
At a glance
| Generic name | Alka Seltzer Extra Strength |
|---|---|
| Sponsor | Bayer |
| Drug class | Antacid combination with analgesic |
| Target | Cyclooxygenase (COX) enzymes; gastric acid neutralization |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology; Pain Management |
| Phase | FDA-approved |
Mechanism of action
The sodium bicarbonate acts as an antacid to neutralize gastric acid and provide rapid relief of heartburn and indigestion. The aspirin provides analgesic and anti-inflammatory effects by inhibiting cyclooxygenase (COX) enzymes and reducing prostaglandin synthesis. The citric acid enhances the effervescent action and aids in rapid dissolution and absorption.
Approved indications
- Heartburn and indigestion relief
- Mild to moderate pain and fever
- Acid reflux symptoms
Common side effects
- Gastrointestinal upset
- Nausea
- Allergic reactions (in aspirin-sensitive individuals)
- Renal effects with chronic use
Key clinical trials
- The Effects of Moviprep With Simethicone on Colonic Bubbles (NA)
- Pharmacokinetic Study Comparing Aspirin and Effervescent Aspirin (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Alka Seltzer Extra Strength CI brief — competitive landscape report
- Alka Seltzer Extra Strength updates RSS · CI watch RSS
- Bayer portfolio CI